NOA1

Entrez Summary: N/A
UniProt Summary: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. {ECO:0000269|PubMed:19103604}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	3/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extrinsic component of mitochondrial inner membrane
regulation of cellular respiration
mitochondrial translation
mitochondrial gene expression
regulation of generation of precursor metabolites and energy
translation
GTP binding
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
apoptotic process
programmed cell death
cell death
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
regulation of cell death
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression