PDCD10

Gene Information

Official Symbol: PDCD10
Official Name: programmed cell death 10
Aliases and Previous Symbols: N/A
Entrez ID: 11235
UniProt: Q9BUL8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q8VE70, ECO:0000269|PubMed:15543491, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:27807006}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.8μM R08 exp435	-2.24
Artemisinin 50μM R08 exp450	-2.22
Benzoate 10000μM R08 exp455	-2.22
Pyridostatin 4μM R05 exp240	-1.99
LY2090314 0.003μM R08 exp499	-1.94
Rapamycin 10μM R00 exp30	-1.9
Rapamycin 2μM R07 exp306	-1.86
CR131-b 0.005μM R08 exp474	-1.85
INK128 0.2μM R02 exp70	-1.82
Lead acetate 2000μM R08 exp497	-1.81
Dynasore 7μM R08 exp436	-1.79
LY2090314 0.003μM R08 exp500 no dilution day6	-1.78
Aphidicolin 0.4μM R08 exp440	-1.73
Staurosporine 0.02μM R08 exp524	-1.72
Wortmannin 5μM R00 exp38	-1.71
iCRT14 30μM R08 exp492	1.81
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.82
Dexamethasone 0.006μM R07 exp351	1.95
Azithromycin 100μM R08 exp452	1.97
Demecolcine 0.03μM R05 exp228	2
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	2.01
Oligomycin-A 2μM R00 exp25	2.09
TRAIL 50ng/ml R00 exp36	2.22
TRAIL 5ng/ml R00 exp35	2.24
Milciclib 2μM R08 exp502	2.34
Mdivi-1 15μM R05 exp217	2.47
UM131593 0.2μM R03 exp106	2.66

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4351
Expression level (log2 read counts): 4.81

Expression Distribution

Gene	Correlation
CCM2	0.51
MESDC1	0.439

programmed cell death in response to reactive oxygen species
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
hydrogen peroxide-mediated programmed cell death
cell death in response to hydrogen peroxide
Golgi reassembly
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
establishment of Golgi localization
organelle inheritance
Golgi inheritance
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Golgi localization
negative regulation of cell migration involved in sprouting angiogenesis
intrinsic apoptotic signaling pathway in response to oxidative stress
contractile actin filament bundle assembly
stress fiber assembly
cell death in response to oxidative stress
negative regulation of sprouting angiogenesis
wound healing, spreading of cells
epiboly involved in wound healing
epiboly
negative regulation of blood vessel endothelial cell migration
negative regulation of endothelial cell proliferation
regulation of cell migration involved in sprouting angiogenesis
negative regulation of endothelial cell migration
morphogenesis of an epithelial sheet
positive regulation of Notch signaling pathway
actin filament bundle assembly
actin filament bundle organization
negative regulation of epithelial cell migration
regulation of sprouting angiogenesis
cellular response to hydrogen peroxide
regulation of blood vessel endothelial cell migration
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
regulation of Notch signaling pathway
negative regulation of angiogenesis
positive regulation of peptidyl-serine phosphorylation
negative regulation of blood vessel morphogenesis
protein N-terminus binding
actomyosin structure organization