PLEKHA2

Entrez Summary: N/A
UniProt Summary: Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Menadione 5μM R06 exp292	-3.45
Lead acetate 2000μM R08 exp497	-2.53
IU1-47 25μM R04 exp182	-2.44
Nifuroxazide 5μM R03 exp102	-2.39
Phenformin 20μM R03 exp143	-2.27
Nutlin-3A 1.6μM R06 exp294	-2.18
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.03
AICAR 240μM R05 exp211	-2
Lead acetate 2000μM R08 exp498 no dilution day6	-2
Benzoate 10000μM R08 exp455	-1.88
iCRT14 30μM R08 exp492	-1.85
Golgicide-A 4μM R03 exp122	-1.81
UNC1999 2μM R03 exp155	-1.75
BI-6727 0.001μM R01 exp42	-1.74
Disulfiram 4.3μM R06 exp281	-1.72
All-trans-Retinoic-Acid 8μM R07 exp333	-1.71
UM131593 0.2μM R03 exp106	1.76
FBS-Wisent 0.1 R07 exp426	1.78
Senexin-A 25μM R07 exp400	1.8
Pomalidomide 20μM R07 exp391	1.88
Thapsigargin 0.005μM R07 exp407	1.98
Nicotinate 1000μM R03 exp140	2.1
BI-6727 0.0125μM R03 exp97	2.17
SB203580 25μM R03 exp149	2.17
Lenalidomide 20μM R07 exp375	2.36
MK2206 4μM R08 exp504	3.08

Expression Distribution

laminin binding
fibronectin binding
phosphatidylinositol-3,4-bisphosphate binding
positive regulation of cell-matrix adhesion
PDZ domain binding
phosphatidylinositol biosynthetic process
regulation of cell-matrix adhesion
positive regulation of cell-substrate adhesion
phosphatidylinositol metabolic process
glycerophospholipid biosynthetic process
regulation of cell-substrate adhesion
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
positive regulation of cell adhesion
organophosphate biosynthetic process
lipid biosynthetic process
protein-containing complex
regulation of cell adhesion
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
membrane