PTBP1

Gene Information

Official Symbol: PTBP1
Official Name: polypyrimidine tract binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 5725
UniProt: P26599
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:21518806}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-2.03
Clomiphene 4.4μM R02 exp68	-1.79
CoCl2 18μM R07 exp346	-1.78
2-Deoxy-D-glucose 800μM R05 exp214	1.71
QNZ 0.01μM R05 exp241	1.76
Ethanol 0.01 R05 exp234	1.77
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.8
Mubritinib 0.2μM R02 exp65	1.85
5-Fluorouracil 2μM R00 exp1	1.92
LB-100 2μM R05 exp210	1.94
UM0125461 0.74μM R02 exp84	1.96
Aminopterin 0.005μM R07 exp335	2.22
Tozasertib 0.1μM R07 exp414	2.52
Latrunculin-B 10μM R07 exp374	3.07

Global Fraction of Cell Lines Where Essential: 89/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	2/26
breast	6/33
central nervous system	3/56
cervix	0/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	9/21
liver	3/20
lung	8/75
lymphocyte	2/16
ovary	3/26
pancreas	4/24
peripheral nervous system	0/16
plasma cell	3/15
prostate	1/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	6/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1368
Expression level (log2 read counts): 8.83

Expression Distribution

poly-pyrimidine tract binding
IRES-dependent viral translational initiation
viral translation
pre-mRNA binding
positive regulation of calcineurin-mediated signaling
positive regulation of calcineurin-NFAT signaling cascade
negative regulation of mRNA splicing, via spliceosome
negative regulation of RNA splicing
negative regulation of mRNA processing
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
positive regulation of calcium-mediated signaling
positive regulation of protein dephosphorylation
negative regulation of muscle cell differentiation
positive regulation of dephosphorylation
regulation of alternative mRNA splicing, via spliceosome
negative regulation of mRNA metabolic process
fibroblast growth factor receptor signaling pathway
regulation of calcium-mediated signaling
regulation of mRNA splicing, via spliceosome
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
viral gene expression
regulation of RNA splicing
regulation of mRNA processing
regulation of protein dephosphorylation
regulation of muscle cell differentiation
regulation of dephosphorylation
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
RNA splicing
mRNA processing
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
mRNA metabolic process
viral process
negative regulation of cell differentiation