RPS20

Entrez Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Screen	Score
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.1
Hippuristanol 0.12μM R08 exp488	-1.87
PF-06409577 20μM R07 exp389	1.89

cytosolic small ribosomal subunit
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
establishment of protein localization to membrane
protein targeting
nucleobase-containing compound catabolic process
translation
peptide biosynthetic process
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
protein localization to membrane
amide biosynthetic process
peptide metabolic process
mRNA metabolic process
viral process
protein localization to organelle
symbiotic process
cellular amide metabolic process
interspecies interaction between organisms
cellular macromolecule catabolic process
intracellular protein transport
macromolecule catabolic process
RNA binding
organonitrogen compound biosynthetic process
protein transport