SAFB

Entrez Summary: N/A
UniProt Summary: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RRM 1
SAP

intracellular estrogen receptor signaling pathway
intracellular steroid hormone receptor signaling pathway
double-stranded DNA binding
steroid hormone mediated signaling pathway
regulation of mRNA processing
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
hormone metabolic process
response to steroid hormone
regulation of mRNA metabolic process
chromatin binding
sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
cellular response to lipid
regulation of hormone levels
cellular response to organic cyclic compound
cellular response to hormone stimulus
regulation of growth
chromatin organization
response to lipid
response to hormone
response to organic cyclic compound
chromosome organization
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
RNA binding
response to endogenous stimulus
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process