SUCLG1

Entrez Summary: This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010].
UniProt Summary: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. {ECO:0000255|HAMAP- Rule:MF_03222}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	-3.28
QNZ 0.01μM R05 exp241	-3.2
Phenformin 20μM R05 exp212	-3.13
QNZ 0.01μM R08 exp439	-2.9
NMS-873 0.07μM R07 exp380	-2.57
Phenformin 20μM R03 exp143	-2.46
Deguelin 0.05μM R02 exp69	-2.33
Nifuroxazide 1μM R01 exp51	-2.32
S-DABN 8μM R03 exp112	-2.32
UM0131023 0.05μM R05 exp248	-2.25
YM155 0.001μM R08 exp432	-2.25
Deguelin 0.15μM R05 exp209	-2
Nifuroxazide 5μM R03 exp102	-1.92
Nifurtimox 1μM R03 exp141	-1.85
SGC2043 10μM R03 exp152	-1.85
Mubritinib 0.2μM R02 exp65	-1.82
Mubritinib 0.2μM R01 exp48	-1.76
Chloramphenicol 20μM R00 exp13	-1.74
MLN-4924 0.2μM R00 exp21	-1.7
Cerivastatin 0.15μM R05 exp226	1.74
Hippuristanol 0.12μM R08 exp488	1.77
Pterostilbene 16μM R02 exp78	1.78
Ammonium tetrathiomolybdate 10μM R08 exp448	1.84
Arsenic trioxide 60μM R08 exp449	1.89
All-trans-Retinoic-Acid 40μM R07 exp334	1.89
EPZ-5676 30μM R05 exp233	2.04
HMS-I2 10μM R06 exp288	2.06
Hypoxia 5%O2 R04 exp191	2.37
Artemisinin 50μM R08 exp450	5.68

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ligase CoA
CoA binding

succinate-CoA ligase (GDP-forming) activity
succinate-CoA ligase (ADP-forming) activity
succinyl-CoA metabolic process
succinate metabolic process
cofactor binding
nucleoside diphosphate kinase activity
tricarboxylic acid cycle
nucleoside diphosphate phosphorylation
nucleotide binding
nucleotide phosphorylation
nucleoside triphosphate biosynthetic process
aerobic respiration
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
dicarboxylic acid metabolic process
acyl-CoA metabolic process
thioester metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
cellular respiration
energy derivation by oxidation of organic compounds
nucleoside phosphate biosynthetic process
coenzyme metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
drug metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
organophosphate metabolic process