TP53BP1

Gene Information

Official Symbol: TP53BP1
Official Name: tumor protein p53 binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 7158
UniProt: Q12888
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:28241136}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 0.1μM R05 exp198	-2.59
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.37
Hippuristanol 0.12μM R08 exp488	-2.24
Genistein 15μM R07 exp360	-2.23
SB202190 10μM R03 exp148	-1.98
IL-3 9ng/ml R08 exp493	-1.95
Beta-Estradiol 0.55μM R07 exp425	-1.94
GSK2606414 1μM R05 exp236	-1.92
UM0011500 5μM R05 exp245	-1.88
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.84
Ribavirin 10 to 15μM on day4 R04 exp160	-1.74
Epigallocatechin gallate 20μM R05 exp230	-1.71
Monensin 0.3μM R08 exp507	1.7
HMS-I1 1μM R01 exp46	1.85
UM131593 0.2μM R03 exp106	2.01
Mdivi-1 15μM R05 exp217	2.17
Taxol 0.004μM R03 exp103	2.6
Vincristine 0.0005μM R04 exp190	3.1
BML-284 0.09μM R08 exp460	3.14

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5648
Expression level (log2 read counts): 6.96

Expression Distribution

ubiquitin modification-dependent histone binding
DNA repair complex
cellular response to X-ray
negative regulation of double-strand break repair via homologous recombination
positive regulation of isotype switching
replication fork
telomeric DNA binding
response to X-ray
negative regulation of double-strand break repair
regulation of isotype switching
negative regulation of DNA repair
positive regulation of B cell mediated immunity
positive regulation of immunoglobulin mediated immune response
positive regulation of DNA recombination
positive regulation of immunoglobulin production
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
chromosome, telomeric region
regulation of B cell mediated immunity
regulation of immunoglobulin mediated immune response
RNA polymerase II activating transcription factor binding
damaged DNA binding
site of double-strand break
double-strand break repair via nonhomologous end joining
methylated histone binding
non-recombinational repair
regulation of immunoglobulin production
p53 binding
cellular response to ionizing radiation
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
transcription coregulator activity
condensed chromosome kinetochore
positive regulation of production of molecular mediator of immune response
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of DNA recombination
positive regulation of lymphocyte mediated immunity
positive regulation of adaptive immune response
nuclear chromosome, telomeric region
negative regulation of DNA metabolic process