UMPS

Gene Information

Official Symbol: UMPS
Official Name: uridine monophosphate synthetase
Aliases and Previous Symbols: N/A
Entrez ID: 7372
UniProt: P11172
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Torin1 0.08μM R02 exp82	-3.24
FK-506 30μM R07 exp359	-2.64
Erlotinib 10μM R05 exp216	-2.48
Radicicol 0.16μM R05 exp242	-2.22
GSK-J4 1-1.25μM to day4 R07 exp363	-2.15
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.11
JQ1 0.01μM R03 exp130	-2.1
Epigallocatechin gallate 20μM R05 exp230	-2.04
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.98
HMS-I1 10μM R06 exp256	-1.92
LJH685 5μM R02 exp73	-1.91
5-Azacytidine 2μM R07 exp330	-1.89
FK-506 5μM R07 exp358	-1.89
Dimethyl-Sulfoxide 1pc R03 exp120	-1.84
Salubrinal 20μM R07 exp399	-1.82
Tunicamycin 0.04μM R07 exp418	-1.82
MK-1775 0.32μM R02 exp75	-1.8
Bisphenol A 100μM R06 exp269	-1.76
Alda-1 10μM R06 exp262	-1.75
ABT-702 5μM R07 exp318	-1.7
Nocodazole 0.2μM R02 exp64	1.7
Apcin 25μM plus proTAME 2μM R04 exp177	1.72
Nicotinate 1000μM R03 exp140	1.79
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.81
S-trityl-L-cysteine 0.5μM R05 exp243	1.85
5-Fluorouracil 2μM R00 exp1	1.95
GSK461364A 0.005μM R03 exp125	2
Myriocin 25μM R06 exp293	2
A-395N 10μM R05 exp219	2.23
Dinaciclib 0.007μM R07 exp355	3.37

Global Fraction of Cell Lines Where Essential: 91/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	14/28
bone	2/26
breast	8/33
central nervous system	1/56
cervix	0/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	4/21
liver	1/20
lung	5/75
lymphocyte	5/16
ovary	0/26
pancreas	5/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 9
Expression level (log2 read counts): 6.4

Expression Distribution

OMPdecase
Pribosyltran

orotate phosphoribosyltransferase activity
orotidine-5-phosphate decarboxylase activity
de novo UMP biosynthetic process
de novo pyrimidine nucleobase biosynthetic process
pyrimidine nucleobase biosynthetic process
UMP biosynthetic process
pyrimidine ribonucleoside monophosphate biosynthetic process
UMP metabolic process
pyrimidine ribonucleoside monophosphate metabolic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleoside biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
nucleobase biosynthetic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine nucleobase metabolic process
pyrimidine ribonucleotide metabolic process
ribonucleoside monophosphate biosynthetic process
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
nucleobase metabolic process
glycosyl compound biosynthetic process
nucleoside monophosphate biosynthetic process
lactation
pyrimidine nucleotide biosynthetic process
ribonucleoside monophosphate metabolic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleoside monophosphate metabolic process
body fluid secretion
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process
mammary gland development
glycosyl compound metabolic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
female pregnancy
multi-multicellular organism process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process