USP36

Gene Information

Official Symbol: USP36
Official Name: ubiquitin specific peptidase 36
Aliases and Previous Symbols: N/A
Entrez ID: 57602
UniProt: Q9P275
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PU-H71 1μM R08 exp515	-1.91
Chloramphenicol 20μM R00 exp13	1.72
PFI-2 4μM R05 exp239	1.73
Alpha-Amanitin 0.5μM R00 exp5	1.79
MLN-4924 0.2μM R00 exp21	1.8
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.87
Rifampicin 10μM R00 exp32	1.94
Wortmannin 5μM R00 exp38	2.32

Gene	Correlation
NUPL1	0.453
TBC1D3G	0.451
KCTD17	0.442
TBC1D3F	0.44
TBC1D3H	0.44
TERF2	0.437
RPS12	0.432
PSMD1	0.431
CHD4	0.424
DTL	0.421
PSMD11	0.419
PLK4	0.418
SHPK	0.416
CCDC64B	0.415
VASN	0.411
UBAP1	0.405
TBC1D3	0.401

Global Fraction of Cell Lines Where Essential: 721/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	26/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	73/75
lymphocyte	14/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1306
Expression level (log2 read counts): 6.98

Expression Distribution

nucleolus organization
regulation of rRNA processing
regulation of ribosome biogenesis
histone deubiquitination
positive regulation of protein targeting to mitochondrion
negative regulation of macroautophagy
regulation of autophagy of mitochondrion
regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
negative regulation of autophagy
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
positive regulation of mitochondrion organization
nucleus organization
positive regulation of intracellular protein transport
regulation of macroautophagy
protein stabilization
regulation of mitochondrion organization
positive regulation of intracellular transport
regulation of intracellular protein transport
negative regulation of cellular catabolic process
protein deubiquitination
regulation of protein stability
protein modification by small protein removal
negative regulation of catabolic process
positive regulation of cellular protein localization
regulation of autophagy
regulation of intracellular transport
histone modification
covalent chromatin modification
nuclear speck
positive regulation of protein transport
positive regulation of establishment of protein localization
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
regulation of cellular protein localization
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process