CRNKL1
Gene Information
- Official Symbol: CRNKL1
- Official Name: crooked neck pre-mRNA splicing factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51340
- UniProt: Q9BZJ0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HAT |
GO Terms
| post-mRNA release spliceosomal complex |
| Prp19 complex |
| U2-type catalytic step 2 spliceosome |
| spliceosomal complex assembly |
| catalytic step 2 spliceosome |
| spliceosomal complex |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| RNA splicing, via transesterification reactions |
| RNA splicing |
| nuclear speck |
| ribonucleoprotein complex biogenesis |
| mRNA processing |
| mRNA metabolic process |
| cellular protein-containing complex assembly |
| RNA processing |
| RNA binding |
| protein-containing complex assembly |
| RNA metabolic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RPS19BP1 | 0.5 |
| NAPA | 0.485 |
| WDR87 | 0.475 |
| DTL | 0.46 |
| NPIPB5 | 0.453 |
| ATP6AP1 | 0.443 |
| TCEB3C | 0.443 |
| CLN6 | 0.44 |
| COPG1 | 0.438 |
| CDC73 | 0.438 |
| MYT1L | 0.436 |
| CCNA2 | 0.432 |
| SUPT5H | 0.43 |
| SLC6A17 | 0.429 |
| DOCK6 | 0.426 |
| TCEB3CL | 0.422 |
| VASN | 0.416 |
| NUFIP2 | 0.413 |
| CHD4 | 0.412 |
| ISCU | 0.411 |
| ORC6 | 0.41 |
| CDCA5 | 0.41 |
| COL2A1 | 0.409 |
| MYO1H | 0.408 |
| ORC1 | 0.408 |
| KCTD17 | 0.404 |
| TSG101 | 0.402 |
| MADCAM1 | 0.4 |
| PSMB2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 679/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 26/28 |
| blood | 28/28 |
| bone | 23/26 |
| breast | 32/33 |
| central nervous system | 48/56 |
| cervix | 3/4 |
| colorectal | 14/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 14/16 |
| kidney | 19/21 |
| liver | 19/20 |
| lung | 69/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 23/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 19/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 19/22 |
| urinary tract | 24/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 1611
- Expression level (log2 read counts): 5.65
Expression Distribution
CRNKL1 Expression in NALM6 Cells: 5.65
