PPIL1

Gene Information

Official Symbol: PPIL1
Official Name: peptidylprolyl isomerase like 1
Aliases and Previous Symbols: N/A
Entrez ID: 51645
UniProt: Q9Y3C6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:16595688}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nutlin-3A 1.6μM R06 exp294	-2.79
VER-155008 3.9μM R06 exp301	-2.73
Mdivi-1 15μM R05 exp217	-2.55
Pterostilbene 16μM R02 exp78	-2.55
UMK57 1μM R01 exp59	-2.54
Nicotine 3000μM R08 exp510	-2.47
Hydroxyurea 100μM R07 exp329	-2.43
Aphidicolin 0.4μM R08 exp440	-2.41
Trimetrexate 0.03μM R08 exp535	-2.34
Resveratrol 16μM R03 exp147	-2.32
Vinblastine 0.002μM R01 exp60	-2.32
Arsenate 40μM R06 exp264	-2.13
JQ1 0.8μM R08 exp435	-2.07
Palbociclib 1μM R07 exp382	-2.07
Diepoxybutane 3μM R07 exp354	-2.05
HMS-I2 10μM R06 exp288	-2.02
Deferoxamine 11μM R07 exp350	-1.97
HMS-I2 5μM R06 exp287	-1.94
Wortmannin 5μM R00 exp38	-1.88
AICAR 240μM R05 exp211	-1.85
TIC10 10μM R08 exp532	-1.85
KU-0063794 3.8μM R02 exp71	-1.84
Rucaparib 6.5μM R08 exp520	-1.81
CoCl2 18μM R07 exp346	-1.79
Docetaxel 0.002μM R01 exp45	-1.79
Vincristine 0.0005μM R04 exp190	-1.77
QNZ 0.01μM R08 exp439	-1.75
Bortezomib 0.005μM R00 exp6	-1.74
Tubacin 1.6μM R07 exp416	-1.73
Centrinone 0.5μM R07 exp343	-1.71
Dinaciclib 0.007μM R07 exp355	-1.71
Isoniazid 100μM R08 exp494	1.71
UM0131023 0.05μM R05 exp248	1.71
Cannabidiol 20μM R08 exp466	2.2

Global Fraction of Cell Lines Where Essential: 197/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	9/28
bone	1/26
breast	10/33
central nervous system	5/56
cervix	0/4
colorectal	4/17
esophagus	6/13
fibroblast	0/1
gastric	4/16
kidney	3/21
liver	5/20
lung	23/75
lymphocyte	8/16
ovary	11/26
pancreas	7/24
peripheral nervous system	7/16
plasma cell	11/15
prostate	0/1
skin	4/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	13/22
urinary tract	10/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 2376
Expression level (log2 read counts): 5.03

Expression Distribution