DCTN6
Gene Information
- Official Symbol: DCTN6
- Official Name: dynactin subunit 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 10671
- UniProt: O00399
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Hexapep |
GO Terms
| dynactin complex |
| condensed chromosome kinetochore |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| antigen processing and presentation of exogenous peptide antigen |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| antigen processing and presentation |
| Golgi vesicle transport |
| centrosome |
| intracellular transport |
| establishment of localization in cell |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| EPRS | 0.51 |
| OSGEP | 0.486 |
| DDX20 | 0.485 |
| VEZT | 0.479 |
| RNMT | 0.458 |
| ATXN10 | 0.456 |
| RPP21 | 0.453 |
| THG1L | 0.449 |
| RBM14 | 0.446 |
| RTCB | 0.445 |
| MED16 | 0.444 |
| GEMIN8 | 0.442 |
| SNAPC5 | 0.436 |
| ADSL | 0.434 |
| GMPPB | 0.432 |
| AARS | 0.428 |
| VRK1 | 0.427 |
| TBCB | 0.427 |
| ALG1 | 0.427 |
| WDR92 | 0.425 |
| DCP2 | 0.422 |
| DCTN5 | 0.42 |
| PMM2 | 0.418 |
| DPAGT1 | 0.416 |
| TBCA | 0.414 |
| MAD2L1 | 0.41 |
| NAE1 | 0.41 |
| BUB3 | 0.409 |
| TSEN34 | 0.409 |
| PAM16 | 0.407 |
| PELO | 0.405 |
| GEMIN6 | 0.402 |
| GNB1L | 0.401 |
| TTI2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 639/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 26/28 |
| blood | 16/28 |
| bone | 23/26 |
| breast | 31/33 |
| central nervous system | 51/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 13/16 |
| kidney | 18/21 |
| liver | 19/20 |
| lung | 68/75 |
| lymphocyte | 13/16 |
| ovary | 23/26 |
| pancreas | 23/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 6/15 |
| prostate | 1/1 |
| skin | 18/24 |
| soft tissue | 7/9 |
| thyroid | 1/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 26/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1278
- Expression level (log2 read counts): 4.46
Expression Distribution
DCTN6 Expression in NALM6 Cells: 4.46
