GOT2
Gene Information
- Official Symbol: GOT2
- Official Name: glutamic-oxaloacetic transaminase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2806
- UniProt: P00505
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:9537447}.
Pfam Domains GO Terms
Pfam Domains
| Aminotran 1 2 |
GO Terms
| glutamate catabolic process to 2-oxoglutarate |
| glutamate catabolic process to aspartate |
| fumarate metabolic process |
| aspartate biosynthetic process |
| L-aspartate:2-oxoglutarate aminotransferase activity |
| 4-hydroxyproline catabolic process |
| kynurenine-oxoglutarate transaminase activity |
| aspartate catabolic process |
| L-kynurenine metabolic process |
| oxaloacetate metabolic process |
| glutamate catabolic process |
| aspartate metabolic process |
| glyoxylate metabolic process |
| kynurenine metabolic process |
| dicarboxylic acid biosynthetic process |
| 4-hydroxyproline metabolic process |
| 2-oxoglutarate metabolic process |
| amino acid binding |
| dicarboxylic acid catabolic process |
| aspartate family amino acid catabolic process |
| aspartate family amino acid biosynthetic process |
| response to muscle activity |
| benzene-containing compound metabolic process |
| glutamine family amino acid catabolic process |
| cellular modified amino acid catabolic process |
| glutamate metabolic process |
| response to isoquinoline alkaloid |
| response to morphine |
| T-tubule |
| gluconeogenesis |
| lactation |
| hexose biosynthetic process |
| aspartate family amino acid metabolic process |
| monosaccharide biosynthetic process |
| cellular aldehyde metabolic process |
| pyridoxal phosphate binding |
| response to activity |
| alpha-amino acid biosynthetic process |
| glutamine family amino acid metabolic process |
| cellular ketone metabolic process |
| fatty acid transport |
| body fluid secretion |
| response to anesthetic |
| cellular amino acid biosynthetic process |
| dicarboxylic acid metabolic process |
| phospholipid binding |
| alpha-amino acid catabolic process |
| response to alkaloid |
| glucose metabolic process |
| cellular amino acid catabolic process |
| carbohydrate biosynthetic process |
| response to ethanol |
| mammary gland development |
| perikaryon |
| monocarboxylic acid transport |
| hexose metabolic process |
| female pregnancy |
| response to ammonium ion |
| cellular modified amino acid metabolic process |
| monosaccharide metabolic process |
| alpha-amino acid metabolic process |
| multi-multicellular organism process |
| response to insulin |
| response to alcohol |
| organic acid catabolic process |
| carboxylic acid catabolic process |
| carboxylic acid transport |
| organic acid transport |
| lipid transport |
| response to xenobiotic stimulus |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| response to antibiotic |
| cellular amino acid metabolic process |
| lipid localization |
| enzyme binding |
| mitochondrial matrix |
| response to peptide hormone |
| mitochondrial inner membrane |
| gland development |
| small molecule catabolic process |
| cofactor metabolic process |
| organic anion transport |
| response to peptide |
| carbohydrate metabolic process |
| regulation of body fluid levels |
| response to toxic substance |
| monocarboxylic acid metabolic process |
| anion transport |
| small molecule biosynthetic process |
| protein-containing complex |
| cell surface |
| protein homodimerization activity |
| response to hormone |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| multi-organism reproductive process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| secretion |
| mitochondrion |
| ion transport |
| RNA binding |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2077
- Expression level (log2 read counts): 7.35
Expression Distribution
GOT2 Expression in NALM6 Cells: 7.35
