MINOS1

Official Symbol: MICOS10
Official Name: mitochondrial contact site and cristae organizing system subunit 10
Aliases and Previous Symbols: N/A
Entrez ID: 440574
UniProt: Q5TGZ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22114354}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM R06 exp261	-2
Alda-1 10μM R06 exp262	-1.9
OICR-9429 10μM R03 exp142	-1.73
Quercetin 20μM R08 exp517	1.73
Tubacin 1.6μM R07 exp416	1.8
CFI-400945 25μM R08 exp469	1.82
Staurosporine 0.02μM R08 exp524	1.92
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.93
Ribavirin 10 to 15μM on day4 R04 exp160	1.95
Tanespimycin 14μM R08 exp527	2.16
QNZ 0.01μM R05 exp241	2.24

Global Fraction of Cell Lines Where Essential: 109/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	9/28
bone	5/26
breast	8/33
central nervous system	9/56
cervix	0/4
colorectal	1/17
esophagus	3/13
fibroblast	0/1
gastric	3/16
kidney	0/21
liver	2/20
lung	9/75
lymphocyte	3/16
ovary	3/26
pancreas	2/24
peripheral nervous system	5/16
plasma cell	4/15
prostate	1/1
skin	1/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	0/5

Expression Distribution