NFATC4
Gene Information
- Official Symbol: NFATC4
- Official Name: nuclear factor of activated T cells 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 4776
- UniProt: Q14934
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RHD |
| TIG |
GO Terms
| negative regulation of synapse maturation |
| cellular response to ionomycin |
| response to ionomycin |
| cellular response to ether |
| brain-derived neurotrophic factor receptor signaling pathway |
| negative regulation of chromatin binding |
| calcineurin-NFAT signaling cascade |
| response to ether |
| peroxisome proliferator activated receptor binding |
| negative regulation of pri-miRNA transcription by RNA polymerase II |
| cellular response to lithium ion |
| regulation of synapse maturation |
| calcineurin-mediated signaling |
| negative regulation of dendrite morphogenesis |
| response to lithium ion |
| regulation of chromatin binding |
| nuclear transcription factor complex |
| negative regulation of synapse organization |
| inositol phosphate-mediated signaling |
| branching involved in blood vessel morphogenesis |
| negative regulation of dendrite development |
| smooth muscle cell differentiation |
| long-term memory |
| regulation of pri-miRNA transcription by RNA polymerase II |
| long-term synaptic potentiation |
| cellular response to fatty acid |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| cellular response to UV |
| response to fatty acid |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of dendrite morphogenesis |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of protein binding |
| cellular response to light stimulus |
| memory |
| branching morphogenesis of an epithelial tube |
| response to UV |
| negative regulation of neuron apoptotic process |
| calcium-mediated signaling |
| intrinsic apoptotic signaling pathway |
| regulation of tumor necrosis factor production |
| muscle cell development |
| cytokine production |
| regulation of dendrite development |
| positive regulation of synaptic transmission |
| regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of neuron projection development |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| cellular respiration |
| negative regulation of binding |
| positive regulation of apoptotic signaling pathway |
| cellular response to radiation |
| negative regulation of cell projection organization |
| regulation of synaptic plasticity |
| cellular response to metal ion |
| transcription factor complex |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| cellular response to acid chemical |
| negative regulation of Wnt signaling pathway |
| regulation of synapse organization |
| regulation of protein binding |
| cellular response to inorganic substance |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| energy derivation by oxidation of organic compounds |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| muscle cell differentiation |
| learning or memory |
| transcription coactivator activity |
| apoptotic signaling pathway |
| negative regulation of neurogenesis |
| cognition |
| regulation of cell morphogenesis involved in differentiation |
| epithelial tube morphogenesis |
| response to light stimulus |
| regulation of neuron death |
| negative regulation of nervous system development |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| angiogenesis |
| transcription factor binding |
| negative regulation of cell development |
| second-messenger-mediated signaling |
| response to acid chemical |
| regulation of Wnt signaling pathway |
| response to metal ion |
| regulation of binding |
| chromatin binding |
| regulation of apoptotic signaling pathway |
| nuclear speck |
| blood vessel morphogenesis |
| generation of precursor metabolites and energy |
| morphogenesis of an epithelium |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of cytokine production |
| muscle structure development |
| transcription by RNA polymerase II |
| blood vessel development |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| inflammatory response |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| heart development |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| tissue morphogenesis |
| behavior |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| RNA biosynthetic process |
| tube morphogenesis |
| regulation of neuron differentiation |
| DNA-binding transcription factor activity |
| regulation of cytokine production |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cellular response to DNA damage stimulus |
| regulation of neurogenesis |
| tube development |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| oxidation-reduction process |
| negative regulation of cell death |
| programmed cell death |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| cell death |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| negative regulation of molecular function |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dimethyloxaloylglycine 100μM R05 exp229 | 1.98 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| C1QTNF9B | 0.506 |
| PRIM1 | 0.497 |
| PSMB4 | 0.495 |
| NUP160 | 0.485 |
| ORC1 | 0.485 |
| RPS2 | 0.484 |
| TBC1D3F | 0.481 |
| HIST1H2BE | 0.479 |
| POLR2J3 | 0.479 |
| RPS12 | 0.475 |
| COPG1 | 0.473 |
| TCEB3CL2 | 0.469 |
| TBC1D3E | 0.468 |
| TBC1D3I | 0.468 |
| TBC1D3L | 0.467 |
| TBC1D3K | 0.467 |
| RPL35 | 0.467 |
| TBC1D3C | 0.467 |
| TCEB3C | 0.464 |
| TCEB3CL | 0.462 |
| TBC1D3H | 0.461 |
| TBC1D3 | 0.461 |
| TBC1D3G | 0.46 |
| TWISTNB | 0.46 |
| KCTD17 | 0.459 |
| ACSF2 | 0.458 |
| CCNA2 | 0.455 |
| VASN | 0.455 |
| COX7A2L | 0.454 |
| TFIP11 | 0.453 |
| CBWD3 | 0.453 |
| TIMELESS | 0.45 |
| NUPL1 | 0.45 |
| CBWD5 | 0.449 |
| UPF1 | 0.447 |
| RRP7A | 0.446 |
| CBWD6 | 0.445 |
| TRAIP | 0.443 |
| SAP30BP | 0.441 |
| UTP3 | 0.441 |
| RBM39 | 0.44 |
| TSPY8 | 0.439 |
| AATF | 0.438 |
| PSMB1 | 0.438 |
| POLA1 | 0.438 |
| PSMA7 | 0.435 |
| HIST2H3A | 0.435 |
| HIST2H3C | 0.435 |
| RPS28 | 0.434 |
| NSF | 0.434 |
| HAP1 | 0.434 |
| CHD4 | 0.433 |
| NUP133 | 0.431 |
| DTL | 0.431 |
| PSMB2 | 0.431 |
| POLE | 0.428 |
| DDTL | 0.428 |
| PSMC2 | 0.428 |
| MED17 | 0.428 |
| ORC6 | 0.427 |
| PSMB3 | 0.427 |
| AKIRIN2 | 0.427 |
| GID4 | 0.424 |
| WDR75 | 0.42 |
| CDC45 | 0.42 |
| PIGS | 0.419 |
| COL2A1 | 0.418 |
| POLR2F | 0.414 |
| MRS2 | 0.414 |
| MT1E | 0.413 |
| ZNF655 | 0.413 |
| PSMA6 | 0.411 |
| EFTUD2 | 0.41 |
| PSAP | 0.408 |
| CDC73 | 0.406 |
| ZNF574 | 0.405 |
| TICRR | 0.405 |
| COPE | 0.404 |
| RPL9 | 0.403 |
| ARCN1 | 0.403 |
| GGA3 | 0.402 |
| COPZ1 | 0.402 |
| COPB1 | 0.402 |
| GPR114 | 0.4 |
| POLR2L | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2223
- Expression level (log2 read counts): 5.34
Expression Distribution
NFATC4 Expression in NALM6 Cells: 5.34
