PIAS4
Gene Information
- Official Symbol: PIAS4
- Official Name: protein inhibitor of activated STAT 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 51588
- UniProt: Q8N2W9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-MIZ |
GO Terms
| positive regulation of keratinocyte apoptotic process |
| transferase complex |
| regulation of keratinocyte apoptotic process |
| positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| SUMO ligase activity |
| positive regulation of protein sumoylation |
| vitamin D metabolic process |
| SUMO transferase activity |
| regulation of protein sumoylation |
| negative regulation of tumor necrosis factor-mediated signaling pathway |
| positive regulation of epithelial cell apoptotic process |
| fat-soluble vitamin metabolic process |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| double-strand break repair via nonhomologous end joining |
| regulation of tumor necrosis factor-mediated signaling pathway |
| positive regulation of intrinsic apoptotic signaling pathway |
| negative regulation of cytokine-mediated signaling pathway |
| RNA polymerase II transcription factor binding |
| non-recombinational repair |
| negative regulation of response to cytokine stimulus |
| protein sumoylation |
| regulation of epithelial cell apoptotic process |
| negative regulation of NF-kappaB transcription factor activity |
| transcription coregulator activity |
| positive regulation of response to DNA damage stimulus |
| PML body |
| nuclear matrix |
| vitamin metabolic process |
| positive regulation of protein modification by small protein conjugation or removal |
| regulation of intrinsic apoptotic signaling pathway |
| negative regulation of DNA-binding transcription factor activity |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of apoptotic signaling pathway |
| regulation of response to cytokine stimulus |
| double-strand break repair |
| protein C-terminus binding |
| regulation of response to DNA damage stimulus |
| regulation of protein modification by small protein conjugation or removal |
| transcription corepressor activity |
| steroid metabolic process |
| ubiquitin protein ligase binding |
| peptidyl-lysine modification |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of apoptotic signaling pathway |
| regulation of DNA-binding transcription factor activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| organic hydroxy compound metabolic process |
| DNA repair |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| regulation of cellular response to stress |
| DNA metabolic process |
| protein modification by small protein conjugation |
| cellular response to DNA damage stimulus |
| zinc ion binding |
| negative regulation of transcription by RNA polymerase II |
| peptidyl-amino acid modification |
| protein modification by small protein conjugation or removal |
| positive regulation of intracellular signal transduction |
| cell-cell signaling |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| lipid metabolic process |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12535
- Expression level (log2 read counts): 4.87
Expression Distribution
PIAS4 Expression in NALM6 Cells: 4.87
