SCD
Gene Information
- Official Symbol: SCD
- Official Name: stearoyl-CoA desaturase
- Aliases and Previous Symbols: N/A
- Entrez ID: 6319
- UniProt: O00767
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| FA desaturase |
GO Terms
| palmitoyl-CoA 9-desaturase activity |
| monounsaturated fatty acid biosynthetic process |
| stearoyl-CoA 9-desaturase activity |
| monounsaturated fatty acid metabolic process |
| fatty-acyl-CoA biosynthetic process |
| fatty-acyl-CoA metabolic process |
| unsaturated fatty acid biosynthetic process |
| regulation of cholesterol biosynthetic process |
| regulation of sterol biosynthetic process |
| thioester biosynthetic process |
| acyl-CoA biosynthetic process |
| regulation of cholesterol metabolic process |
| nucleoside bisphosphate biosynthetic process |
| purine nucleoside bisphosphate biosynthetic process |
| ribonucleoside bisphosphate biosynthetic process |
| regulation of alcohol biosynthetic process |
| response to fatty acid |
| regulation of steroid biosynthetic process |
| fatty acid derivative biosynthetic process |
| acyl-CoA metabolic process |
| thioester metabolic process |
| positive regulation of cold-induced thermogenesis |
| integral component of endoplasmic reticulum membrane |
| unsaturated fatty acid metabolic process |
| regulation of steroid metabolic process |
| fatty acid biosynthetic process |
| oxidoreductase activity |
| ribonucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| iron ion binding |
| coenzyme biosynthetic process |
| regulation of cold-induced thermogenesis |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| fatty acid derivative metabolic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| sulfur compound biosynthetic process |
| monocarboxylic acid biosynthetic process |
| regulation of lipid biosynthetic process |
| cofactor biosynthetic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| purine ribonucleotide metabolic process |
| fatty acid metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| response to acid chemical |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| regulation of lipid metabolic process |
| regulation of small molecule metabolic process |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| cellular amide metabolic process |
| response to lipid |
| nucleolus |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| oxidation-reduction process |
| oxoacid metabolic process |
| endoplasmic reticulum |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| response to oxygen-containing compound |
| cellular nitrogen compound biosynthetic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Bisphenol F 50μM R08 exp457 | -2.93 |
| FTY720 3μM R08 exp483 | -2.77 |
| MSC2530818 10μM R07 exp379 | -2.15 |
| Wiskostatin 3μM R07 exp422 | -2.11 |
| RS-1 10μM R08 exp519 | -2.03 |
| Tubacin 1.6μM R07 exp416 | -2.03 |
| Pomalidomide 20μM R07 exp391 | -1.91 |
| GW501516 25μM R06 exp285 | -1.86 |
| Etoposide 10μM R00 exp20 | -1.79 |
| Daidzin 10μM R06 exp280 | -1.77 |
| Lead acetate 2000μM R08 exp497 | 1.72 |
| JQ1 0.8μM R08 exp435 | 1.74 |
| ML-792 0.2μM R08 exp505 | 1.81 |
| MS023 2μM R03 exp134 | 1.87 |
| CR131-b 0.005μM R08 exp474 | 2.56 |
| Sulforaphane 9μM R08 exp525 | 2.56 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 125/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 9/28 |
| blood | 8/28 |
| bone | 1/26 |
| breast | 4/33 |
| central nervous system | 4/56 |
| cervix | 1/4 |
| colorectal | 6/17 |
| esophagus | 4/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 5/21 |
| liver | 2/20 |
| lung | 16/75 |
| lymphocyte | 3/16 |
| ovary | 2/26 |
| pancreas | 6/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 6/24 |
| soft tissue | 1/9 |
| thyroid | 1/2 |
| upper aerodigestive | 7/22 |
| urinary tract | 5/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4785
- Expression level (log2 read counts): 9.13
Expression Distribution
SCD Expression in NALM6 Cells: 9.13
