UROD
Gene Information
- Official Symbol: UROD
- Official Name: uroporphyrinogen decarboxylase
- Aliases and Previous Symbols: N/A
- Entrez ID: 7389
- UniProt: P06132
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010].
- UniProt Summary: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 80
- Expression level (log2 read counts): 5.02
UROD Expression in NALM6 Cells: 5.02
