Table of Contents

Golgicide-A 2μM R03 exp121

Mechanism of Action

Inhibits cis-Golgi ArfGEF, blocks secretion at ER-Golgi

Technical Notes

Protein References

  • PubChem Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
  • Synonyms: N/A
  • CAS #: 1005036-73-6
  • PubChem CID: 3154410
  • IUPAC: 6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
  • INCHI Name: InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2
  • INCHI Key: NJZHEQOUHLZCOX-UHFFFAOYSA-N
  • Molecular Weight: 284.3
  • Canonical SMILES: C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4
  • Isomeric SMILES: N/A
  • Molecular Formula: C17H14F2N2

Protein Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: G0923
  • Lot #: 105M4619V

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H14F2N2 285.11978; found 285.11995

Dose Response Curve

Dose response curve not available.

Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
1/0ScoresViewViewViewViewView