Table of Contents

Cabazitaxel 0.001μM R05 exp223

Mechanism of Action

Microtubule stabilizer, semi-synthetic taxane

Technical Notes

Protein References

  • PubChem Name: Cabazitaxel
  • Synonyms: XRP6258; RPR-116258A; taxoid XRP6258
  • CAS #: 183133-96-2
  • PubChem CID: 9854073
  • IUPAC: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
  • INCHI Name: InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
  • INCHI Key: BMQGVNUXMIRLCK-OAGWZNDDSA-N
  • Molecular Weight: 835.9
  • Canonical SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
  • Isomeric SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
  • Molecular Formula: C45H57NO14

Protein Supplier

  • Supplier Name: APExBIO
  • Catalog #: B2157
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C45H57NO14 836.38518; found 836.38653

Dose Response Curve

  • Platform ID: Cabazitaxel
  • Min: 10.7396; Max: 88.0253





IC Concentration (µM)
IC10 N/A
IC20 0.0006
IC30 0.0008
IC40 0.0011
IC50 0.0015
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
20/1ScoresViewViewViewViewView