Table of Contents

Rifampicin 30μM R08 exp430

Mechanism of Action

Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes

Technical Notes

Protein References

  • PubChem Name: Rifampicin
  • Synonyms: Rifampin; Rifamycin AMP
  • CAS #: 13292-46-1
  • PubChem CID: 135398735
  • IUPAC: [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
  • INCHI Name: InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
  • INCHI Key: JQXXHWHPUNPDRT-WLSIYKJHSA-N
  • Molecular Weight: 822.9
  • Canonical SMILES: CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
  • Isomeric SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
  • Molecular Formula: C43H58N4O12

Protein Supplier

  • Supplier Name: Med Chem Express
  • Catalog #: HY-B0272
  • Lot #: 33587

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C43H58N4O12 823.4124; found 823.4128

Dose Response Curve

  • Platform ID: Rifampicin
  • Min: -6.7213; Max: 44.6632





IC Concentration (µM)
IC10 6.1970
IC20 17.2600
IC30 34.1100
IC40 59.6000
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/0ScoresViewViewViewViewView