PNO1

Entrez Summary: N/A
UniProt Summary: Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604). {ECO:0000269|PubMed:25851604}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.1μM R03 exp126	-2.42
BI-6727 0.0125μM R03 exp97	-2.25
BI-2536 0.02μM R03 exp96	-2.01
WYE-354 6μM R02 exp90	-1.73
Docosahexaenoic-acid 50μM R07 exp356	1.72
PT-1 25μM R07 exp392	1.72
BH1 1μM R04 exp169	1.74
CCT251545 20μM R07 exp326	1.74
Dynasore 10μM R04 exp180	1.77
Q15 2.7μM R02 exp79	1.85
B02 10μM R08 exp453	1.86
Taxol 0.002μM R01 exp54	1.89
UM0011500 5μM R05 exp245	1.9
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.91
Nicotine 3000μM R08 exp510	1.95
CB-839 10μM R05 exp224	1.98
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.02
GSK-J4 1-1.25μM to day4 R07 exp363	2.03
TNF-alpha 44ng/ml R08 exp533	2.06
CyclicAMP 200μM R08 exp475	2.1
Chloroquine 32μM R08 exp470	2.17
Temozolomide 200μM R04 exp189	2.58
Dihydrosphingosine 8μM R08 exp476	2.76
MSC2530818 10μM R07 exp379	2.8
NN-Diethyl-meta-toluamide 100μM R05 exp237	2.86

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleolus
RNA binding