PPIL1

Entrez Summary: N/A
UniProt Summary: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:16595688}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 197/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	9/28
bone	1/26
breast	10/33
central nervous system	5/56
cervix	0/4
colorectal	4/17
esophagus	6/13
fibroblast	0/1
gastric	4/16
kidney	3/21
liver	5/20
lung	23/75
lymphocyte	8/16
ovary	11/26
pancreas	7/24
peripheral nervous system	7/16
plasma cell	11/15
prostate	0/1
skin	4/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	13/22
urinary tract	10/29
uterus	1/5

Expression Distribution

cyclosporin A binding
U2-type catalytic step 2 spliceosome
disordered domain specific binding
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
peptidyl-proline modification
catalytic step 2 spliceosome
protein folding
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
peptidyl-amino acid modification
RNA metabolic process
gene expression