Isonicotinamide 500μM R03 exp129
Mechanism of Action
nicotinamide antagonist, putative SIRT1 activator
- Class / Subclass 1: Metabolism / Metabolite
Technical Notes
Compound References
- PubChem Name: Isonicotinamide
- Synonyms: N/A
- CAS #: 1453-82-3
- PubChem CID: 15074
- IUPAC: pyridine-4-carboxamide
- INCHI Name: InChI=1S/C6H6N2O/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)
- INCHI Key: VFQXVTODMYMSMJ-UHFFFAOYSA-N
- Molecular Weight: 122.12
- Canonical SMILES: C1=CN=CC=C1C(=O)N
- Isomeric SMILES: N/A
- Molecular Formula: C6H6N2O
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: I17451
- Lot #: BCBD6627V
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C6H6N2O 123.05529; found 123.05433
Dose Response Curve
- Platform ID: ISONICOTINAMIDE
- Min: -8.6917; Max: 18.3168
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 500µM
- Days of incubation: 8
- Doublings: 7.7
- Numbers of reads: 8871155
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/1 | Scores |
Isonicotinamide 500μM R03 exp129
