ABT-702 5μM R06 exp261
Mechanism of Action
Inhibits adenosine kinase (ADK)
- Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor
Technical Notes
Compound References
- PubChem Name: Adenosine Kinase Inhibitor
- Synonyms: N/A
- CAS #: 1188890-28-9
- PubChem CID: 16760265
- IUPAC: 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride
- INCHI Name: InChI=1S/C22H19BrN6O.2ClH/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29;;/h1-5,10-13H,6-9H2,(H2,24,26,27,28);2*1H
- INCHI Key: OOXNYFKPOPJIOT-UHFFFAOYSA-N
- Molecular Weight: 536.2
- Canonical SMILES: C1COCCN1C2=NC=C(C=C2)C3=NC4=NC=NC(=C4C(=C3)C5=CC(=CC=C5)Br)N.Cl.Cl
- Isomeric SMILES: N/A
- Molecular Formula: C22H21BrCl2N6O
Compound Supplier
- Supplier Name: Tocris Bioscience
- Catalog #: 2372
- Lot #: 1B/195137
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H19BrN6O 463.08765; found 463.08744
Dose Response Curve
- Platform ID: ABT-702
- Min: -17.1478; Max: 50.6783
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 27.2987 |
| IC30 | 35.4200 |
| IC40 | 43.8496 |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 5µM
- Days of incubation: 8
- Doublings: 7.1
- Numbers of reads: 7794730
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/1 | Scores |
ABT-702 5μM R06 exp261
