Isoniazid 100μM R08 exp494 [The Human Chemical-Genetic Interaction Map Project]

Inhibits fatty acid synthases, pro-drug activated by catalase-peroxidase KatG

Class / Subclass 1: Infectious Disease / Antibiotic

Compound References

PubChem Name: Isoniazid
Synonyms: INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
CAS #: 54-85-3
PubChem CID: 3767
IUPAC: pyridine-4-carbohydrazide
INCHI Name: InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
INCHI Key: QRXWMOHMRWLFEY-UHFFFAOYSA-N
Molecular Weight: 137.14
Canonical SMILES: C1=CN=CC=C1C(=O)NN
Isomeric SMILES: N/A
Molecular Formula: RPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKDGDWNEFRR

Compound Supplier

Supplier Name: Combi-Blocks
Catalog #: QE-0718
Lot #: B14776

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C6H7N3O 138.06619; found 138.06497

Dose Response Curve

Platform ID: Isoniazid
Min: -6.5476; Max: 43.9660

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 100µM
Days of incubation: 8
Doublings: 7.0
Numbers of reads: 17785019

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
KCNH8	-2.46	0.54
NOC3L	-2.42	0.64
CPNE1	-2.31	0.54
CEP164	-2.29	0.54
CETN1	-2.28	0.54
EPT1	-2.20	0.54
ANXA11	-2.18	0.54
USP19	-2.14	0.54
SLC30A5	-2.13	0.54
TBCA	-2.09	0.54
GEMIN8	-2.05	0.67
ATP5J	-2.03	0.54
DDOST	-2.01	0.71
P2RY2	-1.99	0.54
C2orf53	-1.98	0.54
ASB3	-1.97	0.58
UBE2U	-1.97	0.54
PGBD4	-1.95	0.54
DKC1	-1.95	0.92
ZNF732	-1.93	0.54
SLC35A4	-1.93	0.54
TNFRSF10D	-1.92	0.54
ACTRT3	-1.91	0.54
WDR59	-1.91	0.54
ZSCAN23	-1.90	0.54
ARNT2	-1.90	0.54
ADPRM	-1.90	0.54
TCAF2	-1.89	0.72
MIR205HG	-1.88	0.92
ODC1	-1.87	0.58
POLA2	1.82	0.94
STARD3	1.83	0.94
CTNNBIP1	1.84	0.85
KCNQ4	1.87	0.85
GABRB3	1.88	0.85
USP17L13	1.89	0.85
ATXN2L	1.89	0.85
RPL8	1.90	0.94
LOC441155	1.90	0.85
F2R	1.91	0.85
PER1	1.92	0.85
MYH13	1.93	0.85
GZMB	1.93	0.85
SPCS1	1.93	0.85
NIPBL	1.95	0.94
DDX39B	1.96	0.85
NRL	1.97	0.85
CENPV	2.02	0.85
DIEXF	2.03	0.88
SRRT	2.06	0.85
SRGAP2B	2.09	0.85
FAM96A	2.13	0.85
NUP93	2.13	0.85
POLE	2.14	0.94
NUDCD1	2.15	0.85
WEE1	2.22	0.86
CFHR5	2.25	0.85
NOTCH2NL	2.35	0.85
SRGAP2C	2.51	0.85
USP17L17	3.14	0.85

Last modified: 2026/01/15 21:36
by 127.0.0.1