ABHD5

Gene Information

Official Symbol: ABHD5
Official Name: abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 51099
UniProt: Q8WTS1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008].
UniProt Summary: Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity). {ECO:0000250|UniProtKB:Q9DBL9, ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:18606822, ECO:0000269|PubMed:18832586}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-2.66
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.36
Dexamethasone 0.006μM R07 exp351	-2.34
All-trans-Retinoic-Acid 40μM R07 exp334	-2.05
Benzoate 20000μM R08 exp456	-1.83
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.83
Calcium Ionophore 0.4μM R07 exp342	-1.82
Cryptotanshinone 12μM R05 exp227	-1.81
Wiskostatin 3μM R07 exp422	-1.72
Chloramphenicol 2μM R00 exp12	1.77
Rapamycin 0.001μM R08 exp429	1.83
Quercetin 20μM R08 exp517	1.89
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	2.13
Caffeine 2600μM R08 exp463	2.17
YM155 0.001μM R08 exp432	2.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9914
Expression level (log2 read counts): 3.28

Expression Distribution

Abhydrolase 6
Abhydrolase 5
Abhydrolase 1

lysophosphatidic acid acyltransferase activity
negative regulation of sequestering of triglyceride
positive regulation of triglyceride catabolic process
positive regulation of lipoprotein lipase activity
positive regulation of triglyceride lipase activity
regulation of sequestering of triglyceride
regulation of triglyceride catabolic process
1-acylglycerol-3-phosphate O-acyltransferase activity
negative regulation of lipid storage
positive regulation of triglyceride metabolic process
regulation of lipoprotein lipase activity
triglyceride lipase activity
positive regulation of lipid catabolic process
carboxylic ester hydrolase activity
regulation of triglyceride metabolic process
phosphatidic acid biosynthetic process
negative regulation of lipid localization
phosphatidic acid metabolic process
regulation of lipid storage
regulation of lipid catabolic process
positive regulation of lipase activity
lipid droplet
regulation of lipase activity
lipid homeostasis
regulation of lipid localization
positive regulation of lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
fatty acid metabolic process
positive regulation of cellular catabolic process
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process
positive regulation of catabolic process
monocarboxylic acid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
positive regulation of hydrolase activity