ARID3A

Gene Information

Official Symbol: ARID3A
Official Name: AT-rich interaction domain 3A
Aliases and Previous Symbols: N/A
Entrez ID: 1820
UniProt: Q99856
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11μM R07 exp409	-2.84
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.55
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.55
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.89
ML-792 0.2μM R08 exp505	-1.76
WYE-354 6μM R02 exp90	-1.71
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.73
UM0131023 0.05μM R05 exp248	1.76
Thapsigargin 0.005μM R07 exp407	1.78
Lead acetate 2000μM R08 exp498 no dilution day6	1.83
Selumetinib 20μM R02 exp81	1.86
Rapamycin 0.001μM R08 exp429	1.87
Rifampicin 30μM R08 exp430	1.88
SNS-032 25μM R07 exp401	1.89
PT-1 25μM R07 exp392	1.99
Ethanol 0.01 R05 exp234	2.11
3-Bromopyruvate 7μM R04 exp175	2.15
Dexamethasone 0.006μM R07 exp351	2.28
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.35
I-BRD9 4μM R07 exp365	2.39
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.99

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6141
Expression level (log2 read counts): 5.36

Expression Distribution

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
signal transduction involved in mitotic DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
mitotic G1/S transition checkpoint
mitotic G1 DNA damage checkpoint
G1 DNA damage checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in cell cycle checkpoint
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
mitotic DNA integrity checkpoint
signal transduction in response to DNA damage
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest
signal transduction by p53 class mediator
DNA damage checkpoint
DNA integrity checkpoint
regulation of G1/S transition of mitotic cell cycle
mitotic cell cycle checkpoint
regulation of cell cycle G1/S phase transition
cell cycle checkpoint
negative regulation of mitotic cell cycle phase transition
membrane raft
negative regulation of cell cycle phase transition
positive regulation of cell cycle process
negative regulation of mitotic cell cycle
RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of cell cycle process
positive regulation of cell cycle
chromatin binding
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
DNA-binding transcription activator activity, RNA polymerase II-specific
negative regulation of cell cycle