ATMIN

Gene Information

Official Symbol: ATMIN
Official Name: ATM interactor
Aliases and Previous Symbols: N/A
Entrez ID: 23300
UniProt: O43313
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732, ECO:0000269|PubMed:22167198}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-2.24
LY2090314 0.003μM R08 exp499	-2.21
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.72
UMK57 1μM R01 exp59	1.72
Vincristine 0.0005μM R04 exp190	1.74
Pterostilbene 16μM R02 exp78	1.75
MK2206 4μM R08 exp504	1.79
Etoposide 0.3μM R05 exp199	1.87
2-Deoxy-D-glucose 800μM R05 exp214	1.93
AICAR 240μM R03 exp116	1.96
Cryptotanshinone 12μM R05 exp227	2
Aphidicolin 0.4μM R08 exp440	2.05
Benzoate 20000μM R08 exp456	2.06
Colchicine 0.009μM R05 exp215	2.06
Doxycycline 10μM R00 exp18	2.16
GSK626616 14μM R08 exp485	2.23
Hippuristanol 0.12μM R08 exp488	2.24
Thapsigargin 0.005μM R07 exp407	2.29
ML-792 0.2μM R08 exp505	2.36
MS023 2μM R03 exp134	2.48
Centrinone 0.5μM R07 exp343	2.9
Latrunculin-B 10μM R07 exp374	3.03
Cytochalasin-B 5μM R07 exp349	3.4
Staurosporine 0.02μM R08 exp524	4.32

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6635
Expression level (log2 read counts): 6.26

Expression Distribution

positive regulation of non-motile cilium assembly
regulation of non-motile cilium assembly
dynein complex binding
motile cilium assembly
positive regulation of cilium assembly
positive regulation of organelle assembly
regulation of cilium assembly
positive regulation of plasma membrane bounded cell projection assembly
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
transcription regulatory region DNA binding
regulation of organelle assembly
nuclear body
cilium assembly
cilium organization
positive regulation of cell projection organization
plasma membrane bounded cell projection assembly
cell projection assembly
positive regulation of cellular component biogenesis
positive regulation of organelle organization
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
organelle assembly
cellular response to DNA damage stimulus
regulation of cellular component biogenesis
plasma membrane bounded cell projection organization
cell projection organization
positive regulation of cellular component organization
regulation of organelle organization
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process