COQ5

Entrez Summary: N/A
UniProt Summary: Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). {ECO:0000255|HAMAP- Rule:MF_03191}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1μM R07 exp362	-1.8
Hydroxyurea 100μM R07 exp329	1.72
Ribavirin 10 to 15μM on day4 R04 exp160	2.03
Ammonium tetrathiomolybdate 10μM R08 exp448	2.82

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity
2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
extrinsic component of mitochondrial inner membrane
quinone biosynthetic process
ubiquinone biosynthetic process
ubiquinone metabolic process
ketone biosynthetic process
quinone metabolic process
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
coenzyme biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
methylation
mitochondrial matrix
mitochondrial inner membrane
cofactor metabolic process
small molecule biosynthetic process
protein-containing complex
mitochondrion
small molecule metabolic process