DGKD

Entrez Summary: This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: May function as signaling molecule. {ECO:0000269|PubMed:17880279}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	1.72
Dinaciclib 0.007μM R07 exp355	1.76
AICAR 240μM R03 exp116	1.8
Diepoxybutane 3μM R07 exp354	1.8
LY2090314 0.003μM R08 exp499	1.88
3-Bromopyruvate 7μM R04 exp175	1.93
Trichostatin-A 0.06μM R07 exp415	1.95
MS023 2μM R03 exp134	2.07
UM0125461 0.74μM R02 exp84	2.08
2-Deoxy-D-glucose 800μM R05 exp214	2.18
Aphidicolin 0.4μM R08 exp440	2.22
Dorsomorphin 5μM R07 exp357	2.41
Lead acetate 2000μM R08 exp498 no dilution day6	2.49
Lead acetate 2000μM R08 exp497	2.53
Ethanol 0.01 R05 exp234	2.7
GSK626616 14μM R08 exp485	2.77
Thapsigargin 0.005μM R07 exp407	2.79
Radicicol 0.16μM R05 exp242	2.96
Milciclib 2μM R08 exp502	3.42

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

diacylglycerol kinase activity
diacylglycerol binding
NAD+ kinase activity
diacylglycerol metabolic process
protein kinase C-activating G protein-coupled receptor signaling pathway
epidermal growth factor receptor signaling pathway
lipid phosphorylation
ERBB signaling pathway
acylglycerol metabolic process
neutral lipid metabolic process
platelet activation
lipid modification
blood coagulation
coagulation
hemostasis
second-messenger-mediated signaling
protein homooligomerization
glycerolipid metabolic process
wound healing
protein heterodimerization activity
regulation of body fluid levels
transmembrane receptor protein tyrosine kinase signaling pathway
protein complex oligomerization
endocytosis
response to wounding
import into cell
enzyme linked receptor protein signaling pathway
protein homodimerization activity
cellular lipid metabolic process
cell activation
lipid metabolic process
phosphorylation
G protein-coupled receptor signaling pathway
ATP binding
protein transport
peptide transport
protein-containing complex assembly
amide transport
establishment of protein localization
intracellular signal transduction