EIF4B

Entrez Summary: N/A
UniProt Summary: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Atovaquone 15μM R08 exp451	-2.68
Nocodazole 0.2μM R00 exp24	-2
UM131593 0.2μM R03 exp106	-1.74
Dimethyloxaloylglycine 11μM R07 exp314	1.72
Staurosporine 0.02μM R08 exp524	1.72
WYE-354 6μM R02 exp90	1.74
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.77
Hypoxia 5%O2 R04 exp191	1.8
GSK-J4 1μM R07 exp362	1.8
LB-100 2μM R05 exp210	1.8
Cytochalasin-B 5μM R07 exp349	1.81
Doxycycline 10μM R00 exp18	1.83
Bortezomib 0.005μM R00 exp6	1.87
Zebularine 20μM R07 exp423	1.89
GSK626616 14μM R08 exp485	1.94
Senexin-A 25μM R07 exp400	1.96
A-769662 20μM R07 exp331	1.99
BI-6727 0.0125μM R03 exp97	2.05
iCRT14 30μM R08 exp492	2.06
Oligomycin-A 2μM R00 exp25	2.06
Thapsigargin 0.005μM R07 exp407	2.07
Olaparib 4μM R08 exp512	2.08
Vemurafenib 6.6μM R08 exp434	2.11
PF-06409577 20μM R07 exp389	2.23
Vemurafenib 6.6μM R02 exp89	2.3
All-trans-Retinoic-Acid 40μM R07 exp334	2.35
Dexamethasone 0.006μM R07 exp351	3.03
Erlotinib 10μM R05 exp216	3.05
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	3.1
MK-1775 0.32μM R02 exp75	3.77

Global Fraction of Cell Lines Where Essential: 46/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	5/26
breast	3/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	0/21
liver	0/20
lung	4/75
lymphocyte	4/16
ovary	3/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA strand-exchange activity
eukaryotic translation initiation factor 4F complex assembly
RNA strand annealing activity
formation of translation preinitiation complex
eukaryotic translation initiation factor 4F complex
ribosomal small subunit binding
cytoplasmic translational initiation
polysome
translation initiation factor activity
cytoplasmic translation
regulation of translational initiation
translational initiation
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
ribonucleoprotein complex biogenesis
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
cellular protein-containing complex assembly
RNA binding
organonitrogen compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression