G3BP1

Entrez Summary: N/A
UniProt Summary: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:9889278}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Methotrexate 0.01μM R08 exp501	-2.62
3-Bromopyruvate 7μM R04 exp175	-2.44
Aminopterin 0.005μM R07 exp335	-2.36
Docetaxel 0.002μM R01 exp45	-2.29
THZ531 0.225μM R08 exp444	-1.94
Bortezomib 0.005μM R00 exp6	-1.85
Taxol 0.004μM R03 exp103	1.7
Deguelin 0.15μM R05 exp209	1.77
DABN 2μM R00 exp16	1.8
Rapamycin 1μM R00 exp29	1.8
Wortmannin 0.5μM R00 exp37	1.83
Mubritinib 0.2μM R02 exp65	1.84
5-Azacytidine 2μM R07 exp330	1.85
Chlorpromazine 10μM R07 exp344	1.85
I-BRD9 4μM R07 exp365	1.92
QNZ 0.01μM R05 exp241	1.92
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.95
GSK-LSD1 10μM R03 exp123	2.15
Vemurafenib 6.6μM R02 exp89	2.18
Rotenone 0.07μM R08 exp431	2.22
PF-06409577 20μM R07 exp389	2.28
AICAR 240μM R03 exp116	2.33
QNZ 0.01μM R08 exp439	2.45
Phenformin 20μM R05 exp212	2.62
Oligomycin-A 2μM R00 exp25	2.89
Vemurafenib 6.6μM R08 exp434	2.93
TRAIL 5ng/ml R00 exp35	3.15
Chloramphenicol 20μM R00 exp13	3.18
TRAIL 50ng/ml R00 exp36	4.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
ELF1	0.48
TNPO1	0.451

NTF2
RRM 1

positive regulation of stress granule assembly
regulation of stress granule assembly
type I interferon production
stress granule assembly
endonuclease activity
DNA helicase activity
RNA helicase activity
cytoplasmic stress granule
positive regulation of organelle assembly
DNA duplex unwinding
DNA geometric change
perikaryon
cytokine production
ribonucleoprotein complex
mRNA binding
negative regulation of canonical Wnt signaling pathway
defense response to virus
negative regulation of Wnt signaling pathway
regulation of organelle assembly
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
Ras protein signal transduction
positive regulation of protein complex assembly
response to virus
regulation of canonical Wnt signaling pathway
DNA conformation change
nucleic acid phosphodiester bond hydrolysis
small GTPase mediated signal transduction
regulation of Wnt signaling pathway
focal adhesion
regulation of protein complex assembly
ribonucleoprotein complex biogenesis
positive regulation of cellular component biogenesis
positive regulation of organelle organization
viral process
organelle assembly
innate immune response
symbiotic process
interspecies interaction between organisms
cellular protein-containing complex assembly