GTF2A2

Gene Information

Official Symbol: GTF2A2
Official Name: general transcription factor IIA subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 2958
UniProt: P52657
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lenalidomide 20μM R07 exp375	-2.31
PFI-2 4μM R05 exp239	-2.15
LJH685 5μM R02 exp73	-1.87
GSK2606414 1μM R05 exp236	-1.8
CVT-10216 0.1μM R06 exp278	-1.79
Calcipotriol 5μM R08 exp464	-1.73
Isoniazid 100μM R08 exp494	-1.7
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.7
HMS-I1 10μM R06 exp256	1.82
Bortezomib 0.05μM R00 exp7	1.92
SNS-032 15μM R08 exp443	1.92
Staurosporine 0.02μM R08 exp524	2.39
GSK461364A 0.1μM R03 exp126	2.71

Gene	Correlation
DPAGT1	0.546
THG1L	0.528
PMM2	0.528
RPTOR	0.5
WDR24	0.492
RNMT	0.489
GMPPB	0.487
CBFB	0.485
DOHH	0.482
SRP14	0.474
UTP23	0.47
ALG1	0.46
LAMTOR4	0.46
WDR59	0.455
TRIAP1	0.449
ALG2	0.445
PELO	0.438
CCDC101	0.438
GNB1L	0.436
UAP1	0.434
TRMT10A	0.432
PPA2	0.426
RPIA	0.425
NAE1	0.421
MED16	0.42
GTF3C2	0.42
ALG13	0.418
LSM10	0.418
CHCHD4	0.416
GFPT1	0.415
ADSL	0.413
UHRF1	0.412
SDHA	0.41
TRMT5	0.409
LAMTOR5	0.409
RTCB	0.408
GTF3C3	0.408
RPP21	0.407
TEN1	0.406
SSBP2	0.406
FNTA	0.406
RFT1	0.406
VPS41	0.405
TAZ	0.403
UBE2G2	0.403

Global Fraction of Cell Lines Where Essential: 693/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	25/28
bone	24/25
breast	30/33
central nervous system	51/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	14/15
kidney	20/21
liver	19/20
lung	73/75
lymphocyte	13/14
ovary	26/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	1/1
skin	21/24
soft tissue	5/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1654
Expression level (log2 read counts): 6.32

Expression Distribution

TFIIA gamma C
TFIIA gamma N

transcription factor TFIIA complex
RNA polymerase II preinitiation complex assembly
RNA polymerase II general transcription initiation factor activity
TBP-class protein binding
transcription preinitiation complex assembly
RNA polymerase II repressing transcription factor binding
transcription factor TFIID complex
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
transcription initiation from RNA polymerase II promoter
protein-DNA complex assembly
DNA-templated transcription, initiation
protein-DNA complex subunit organization
positive regulation of DNA-binding transcription factor activity
transcription coactivator activity
transcription factor binding
regulation of DNA-binding transcription factor activity
transcription by RNA polymerase II
protein heterodimerization activity
cell junction
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
viral process
symbiotic process
interspecies interaction between organisms
cellular protein-containing complex assembly
protein homodimerization activity
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process