HEATR3

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.1μM R01 exp58	-2.29
Nutlin-3A 1.6μM R06 exp294	-1.7
CB-839 10μM R05 exp224	1.71
Rucaparib 6.5μM R08 exp520	1.73
Citral 75μM R06 exp275	1.74
Milciclib 2μM R08 exp502	1.76
3-Bromopyruvate 7μM R04 exp175	1.79
Rotenone 0.07μM R08 exp431	1.79
I-BRD9 4μM R07 exp365	1.82
Atovaquone 15μM R08 exp451	1.87
QNZ 0.01μM R08 exp439	1.87
Dinaciclib 0.007μM R07 exp355	1.95
Actinomycin-D 0.01μM R00 exp4	1.98
Phenformin 20μM R05 exp212	1.98
BI-D1870 3.15μM R02 exp66	2.02
Olaparib 4μM R08 exp512	2.04
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.04
Thapsigargin 0.005μM R07 exp407	2.09
Amiloride 100μM R08 exp447	2.19
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.22
Trimetrexate 0.03μM R08 exp535	2.23
Nifuroxazide 5μM R03 exp102	2.3
Quinacrine 2.5μM R03 exp146	2.5
Ethanol 0.01 R05 exp234	2.51
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.56
Diepoxybutane 3μM R07 exp354	2.57
MLN-4924 0.2μM R00 exp21	2.63
Pyridostatin 4μM R05 exp240	2.72
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.75
Talazoparib 0.006μM R06 exp299	2.89
MS023 2μM R03 exp134	3.08
ML-792 0.2μM R08 exp505	3.36
AICAR 240μM R05 exp211	3.65
THZ531 0.225μM R08 exp444	3.91
AICAR 240μM R03 exp116	4.05
GSK626616 14μM R08 exp485	4.61
5-Fluorouracil 20μM R00 exp2	5.16
Actinomycin-D 0.001μM R00 exp3	6.6

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ribosomal large subunit biogenesis
cell
protein import into nucleus
import into nucleus
unfolded protein binding
protein import
protein localization to nucleus
nucleocytoplasmic transport
nuclear transport
ribosome biogenesis
establishment of protein localization to organelle
ribonucleoprotein complex biogenesis
protein localization to organelle
intracellular protein transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport