HSPA5
Gene Information
- Official Symbol: HSPA5
- Official Name: heat shock protein family A (Hsp70) member 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 3309
- UniProt: P11021
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010].
- UniProt Summary: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:28332555}.
Pfam Domains GO Terms
Pfam Domains
| HSP70 |
| MreB Mbl |
GO Terms
| regulation of protein folding in endoplasmic reticulum |
| response to methamphetamine hydrochloride |
| cerebellum structural organization |
| hindbrain structural organization |
| negative regulation of IRE1-mediated unfolded protein response |
| negative regulation of protein homodimerization activity |
| regulation of ATF6-mediated unfolded protein response |
| posttranslational protein targeting to membrane, translocation |
| luteolysis |
| ATF6-mediated unfolded protein response |
| regulation of protein folding |
| regulation of PERK-mediated unfolded protein response |
| negative regulation of endoplasmic reticulum unfolded protein response |
| endoplasmic reticulum chaperone complex |
| positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| posttranslational protein targeting to endoplasmic reticulum membrane |
| regulation of IRE1-mediated unfolded protein response |
| PERK-mediated unfolded protein response |
| ER overload response |
| maintenance of protein localization in endoplasmic reticulum |
| cellular response to manganese ion |
| protein folding in endoplasmic reticulum |
| anatomical structure arrangement |
| stress response to metal ion |
| response to salt |
| response to manganese ion |
| ATPase activity, coupled |
| regulation of protein homodimerization activity |
| protein folding chaperone |
| regulation of endoplasmic reticulum unfolded protein response |
| cerebellar Purkinje cell layer development |
| misfolded protein binding |
| smooth endoplasmic reticulum |
| cellular response to interleukin-4 |
| cellular response to gamma radiation |
| positive regulation of transcription from RNA polymerase II promoter in response to stress |
| response to interleukin-4 |
| chaperone cofactor-dependent protein refolding |
| ER-nucleus signaling pathway |
| COP9 signalosome |
| cerebellum morphogenesis |
| de novo posttranslational protein folding |
| protein refolding |
| toxin transport |
| maintenance of protein localization in organelle |
| de novo protein folding |
| hindbrain morphogenesis |
| cellular response to glucose starvation |
| substantia nigra development |
| ovulation cycle process |
| negative regulation of response to endoplasmic reticulum stress |
| neuron apoptotic process |
| cerebellar cortex development |
| intracellular protein transmembrane transport |
| cellular response to nerve growth factor stimulus |
| response to nerve growth factor |
| neuron death |
| cellular response to cAMP |
| response to cocaine |
| ribosome binding |
| IRE1-mediated unfolded protein response |
| response to gamma radiation |
| heat shock protein binding |
| chaperone-mediated protein folding |
| protein transmembrane transport |
| neural nucleus development |
| ovulation cycle |
| cellular response to ionizing radiation |
| cellular response to heat |
| ubiquitin-dependent ERAD pathway |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| maintenance of protein location in cell |
| endoplasmic reticulum-Golgi intermediate compartment |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| response to anesthetic |
| cellular response to calcium ion |
| regulation of response to endoplasmic reticulum stress |
| midbrain development |
| female gonad development |
| ERAD pathway |
| development of primary female sexual characteristics |
| maintenance of location in cell |
| response to cAMP |
| melanosome |
| chaperone binding |
| negative regulation of protein binding |
| cerebellum development |
| endoplasmic reticulum unfolded protein response |
| maintenance of protein location |
| female sex differentiation |
| integral component of endoplasmic reticulum membrane |
| protein targeting to ER |
| response to heat |
| metencephalon development |
| response to alkaloid |
| regulation of transforming growth factor beta receptor signaling pathway |
| establishment of protein localization to endoplasmic reticulum |
| regulation of cellular response to transforming growth factor beta stimulus |
| positive regulation of protein ubiquitination |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to antibiotic |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| regulation of DNA-templated transcription in response to stress |
| cellular response to unfolded protein |
| unfolded protein binding |
| positive regulation of protein modification by small protein conjugation or removal |
| protein localization to endoplasmic reticulum |
| response to organophosphorus |
| negative regulation of cellular response to growth factor stimulus |
| cellular response to topologically incorrect protein |
| response to ionizing radiation |
| cellular response to starvation |
| hindbrain development |
| response to calcium ion |
| response to purine-containing compound |
| midbody |
| protein targeting to membrane |
| response to unfolded protein |
| maintenance of location |
| negative regulation of binding |
| cellular response to radiation |
| response to temperature stimulus |
| response to ammonium ion |
| response to topologically incorrect protein |
| cellular response to metal ion |
| response to starvation |
| regulation of protein ubiquitination |
| gonad development |
| cellular response to biotic stimulus |
| development of primary sexual characteristics |
| regulation of protein binding |
| cellular response to inorganic substance |
| regulation of protein modification by small protein conjugation or removal |
| protein folding |
| cellular response to nutrient levels |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| ATPase activity |
| protein domain specific binding |
| response to endoplasmic reticulum stress |
| establishment of protein localization to membrane |
| cellular response to extracellular stimulus |
| sex differentiation |
| regulation of cellular response to growth factor stimulus |
| rhythmic process |
| positive regulation of neuron projection development |
| ubiquitin protein ligase binding |
| response to xenobiotic stimulus |
| response to antibiotic |
| endoplasmic reticulum lumen |
| cadherin binding |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| cellular response to external stimulus |
| enzyme binding |
| proteasomal protein catabolic process |
| protein targeting |
| positive regulation of neuron differentiation |
| response to metal ion |
| regulation of binding |
| positive regulation of cell projection organization |
| cellular response to drug |
| focal adhesion |
| reproductive structure development |
| reproductive system development |
| establishment of protein localization to organelle |
| response to radiation |
| positive regulation of neurogenesis |
| protein localization to membrane |
| regulation of neuron projection development |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| positive regulation of cell motility |
| ubiquitin-dependent protein catabolic process |
| response to extracellular stimulus |
| response to growth factor |
| modification-dependent protein catabolic process |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of cell development |
| modification-dependent macromolecule catabolic process |
| positive regulation of locomotion |
| proteolysis involved in cellular protein catabolic process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| cell surface |
| cellular protein catabolic process |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| calcium ion binding |
| regulation of cellular response to stress |
| protein localization to organelle |
| brain development |
| head development |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| regulation of cell migration |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| regulation of cell motility |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| endoplasmic reticulum membrane |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| intracellular protein transport |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| neuron differentiation |
| response to drug |
| macromolecule catabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| cell death |
| response to cytokine |
| negative regulation of molecular function |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| mitochondrion |
| negative regulation of signal transduction |
| proteolysis |
| transmembrane transport |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 683/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 25/28 |
| blood | 28/28 |
| bone | 22/26 |
| breast | 30/33 |
| central nervous system | 52/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 19/21 |
| liver | 20/20 |
| lung | 70/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 27/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 195
- Expression level (log2 read counts): 10.51
Expression Distribution
HSPA5 Expression in NALM6 Cells: 10.51
