NIP7

Entrez Summary: N/A
UniProt Summary: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. {ECO:0000269|PubMed:22195017}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Screen	Score
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.79
Daidzin 10μM R06 exp280	1.95

preribosome, large subunit precursor
ribosome assembly
ribosomal large subunit biogenesis
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
ribonucleoprotein complex biogenesis
organelle assembly
cellular protein-containing complex assembly
nucleolus
RNA binding
protein-containing complex assembly
protein-containing complex subunit organization