PDHB

Entrez Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012].
UniProt Summary: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.25
Q15 2.7μM R02 exp79	-1.91
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.85
Deguelin 0.05μM R02 exp69	1.76
Deguelin 0.15μM R05 exp209	1.8
YM155 0.001μM R08 exp432	1.83
Prochlorperazine 5.2μM R02 exp77	1.95
Nifuroxazide 1μM R01 exp51	1.96
QNZ 0.01μM R05 exp241	2.12
Trametinib 10μM R02 exp83	2.16
Rotenone 0.07μM R08 exp431	2.29
IU1-C 25μM R04 exp183	2.8
Citral 50μM R06 exp274	4.93
Nifuroxazide 5μM R03 exp102	7.55

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Transketolase C
Transket pyr

pyruvate dehydrogenase activity
pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase complex
mitochondrial acetyl-CoA biosynthetic process from pyruvate
pyruvate dehydrogenase (NAD+) activity
acetyl-CoA biosynthetic process from pyruvate
acetyl-CoA biosynthetic process
acetyl-CoA metabolic process
tricarboxylic acid cycle
thioester biosynthetic process
acyl-CoA biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
ribonucleoside bisphosphate biosynthetic process
pyruvate metabolic process
aerobic respiration
acyl-CoA metabolic process
thioester metabolic process
glucose metabolic process
ribonucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
hexose metabolic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
cellular respiration
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
monosaccharide metabolic process
cofactor biosynthetic process
energy derivation by oxidation of organic compounds
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process