SARS

Entrez Summary: N/A
UniProt Summary: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser- AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp497	-2.83
CAY10603 0.55μM R08 exp467	-2.73
Thapsigargin 0.005μM R07 exp407	-2.6
Vemurafenib 6.6μM R08 exp434	-2.49
Mubritinib 0.2μM R02 exp65	-2.4
5-Azacytidine 2μM R07 exp330	-2.28
MKC9989 10μM R03 exp133	-2.24
DABN racemic mixture R03 exp93	-2.21
Rucaparib 6.5μM R08 exp520	-2.18
Dorsomorphin 5μM R07 exp357	-2.17
Cincreasin 100μM R08 exp473	-2.15
ML-792 0.2μM R08 exp505	-2.11
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.07
Docetaxel 0.002μM R01 exp45	-2.05
GSK626616 14μM R08 exp485	-2.02
Rotenone 0.07μM R08 exp431	-2
Dihydrosphingosine 8μM R08 exp476	-1.98
Olaparib 4μM R08 exp512	-1.88
OICR-9429 10μM R03 exp142	-1.72
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.71
Bortezomib 0.05μM R00 exp7	1.73
CI-1040 9.5μM R08 exp472	1.78
SNS-032 25μM R07 exp401	1.78
THZ1 0.06μM R08 exp531	1.8
Sulforaphane 9μM R08 exp526 no dilution day6	1.82
Benzoate 20000μM R08 exp456	2.06
Atovaquone 15μM R08 exp451	2.09
IL-3 9ng/ml R08 exp493	2.11
Etoposide 1μM R00 exp19	2.13
Cannabidiol 13μM R08 exp465	2.74
CFI-400945 25μM R08 exp469	2.81
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.81

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

tRNA-synt 2b
Seryl tRNA N

seryl-tRNA aminoacylation
serine-tRNA ligase activity
negative regulation of vascular endothelial growth factor production
selenocysteinyl-tRNA(Sec) biosynthetic process
selenocysteine metabolic process
regulation of vascular endothelial growth factor production
serine family amino acid metabolic process
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
tRNA processing
tRNA metabolic process
alpha-amino acid metabolic process
negative regulation of cytokine production
regulation of angiogenesis
cellular amino acid metabolic process
regulation of vasculature development
translation
ncRNA processing
peptide biosynthetic process
ncRNA metabolic process
RNA polymerase II proximal promoter sequence-specific DNA binding
amide biosynthetic process
peptide metabolic process
RNA biosynthetic process
regulation of cytokine production
cellular amide metabolic process
negative regulation of transcription by RNA polymerase II
RNA processing
protein homodimerization activity
carboxylic acid metabolic process
negative regulation of developmental process
oxoacid metabolic process
organic acid metabolic process
regulation of anatomical structure morphogenesis
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process