SATB2

Entrez Summary: This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010].
UniProt Summary: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.26
Dorsomorphin 5μM R07 exp357	-2.16
Cytochalasin-B 5μM R07 exp349	-2.13
FK-506 30μM R07 exp359	-2.04
Lead acetate 2000μM R08 exp498 no dilution day6	-2.03
CCT251545 20μM R07 exp326	-2.02
Fluvastatin 2.2μM R06 exp282	-1.93
Lead acetate 2000μM R08 exp497	-1.93
2-Methoxyestradiol 0.2μM R01 exp40	-1.92
Olaparib 4μM R08 exp512	-1.87
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.81
Parthenolide 2.5μM R05 exp238	-1.8
Latrunculin-B 10μM R07 exp374	-1.77
All-trans-Retinoic-Acid 40μM R07 exp334	-1.76
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.75
CCCP 1μM R00 exp11	-1.73
BN82002 4μM R07 exp340	-1.7
CAY10603 0.55μM R08 exp467	1.76
Thapsigargin 0.005μM R07 exp407	1.78

Global Fraction of Cell Lines Where Essential: 7/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
CUT

commitment of neuronal cell to specific neuron type in forebrain
forebrain neuron fate commitment
osteoblast development
histone deacetylase complex
forebrain neuron differentiation
embryonic pattern specification
neuron fate commitment
forebrain generation of neurons
roof of mouth development
embryonic skeletal system morphogenesis
nuclear matrix
neuron migration
embryonic skeletal system development
osteoblast differentiation
chromatin remodeling
cartilage development
central nervous system neuron differentiation
transcription factor complex
connective tissue development
skeletal system morphogenesis
cell fate commitment
ossification
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
forebrain development
chromatin binding
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
chromatin organization
brain development
head development
negative regulation of transcription by RNA polymerase II
animal organ morphogenesis
cell migration