TIPRL

Entrez Summary: N/A
UniProt Summary: May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681, ECO:0000269|PubMed:26717153}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 10μM R00 exp30	-2.34
MK-1775 0.32μM R02 exp75	-2.01
INK128 0.2μM R02 exp70	-1.98
Torin1 0.08μM R02 exp82	-1.83
Senexin-A 25μM R07 exp400	1.8
Radicicol 0.16μM R05 exp242	1.82
Artemisinin 50μM R08 exp450	1.83
Methotrexate 0.01μM R08 exp501	1.85
2-Methoxyestradiol 0.55μM R07 exp310	2.01
Arsenate 40μM R06 exp264	2.04
BML-284 0.09μM R08 exp460	2.05
VER-155008 3.9μM R06 exp301	2.06
Palbociclib 1μM R07 exp382	2.1
Aminopterin 0.005μM R07 exp335	2.12
Bisphenol S 100μM R08 exp458	2.2
Thapsigargin 0.005μM R07 exp407	2.36
Colchicine 0.009μM R05 exp215	2.5
HMS-I1 1μM R01 exp46	2.57
Mdivi-1 15μM R05 exp217	2.83
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.85
Milciclib 2μM R08 exp502	3.37
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	3.65
UMK57 1μM R01 exp59	4.15
BVD-523 15μM R02 exp67	4.51
RO-3307 4.7μM R02 exp80	5.04

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	2/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Expression Distribution

TOR signaling
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
DNA damage checkpoint
regulation of protein dephosphorylation
DNA integrity checkpoint
regulation of phosphatase activity
cell cycle checkpoint
regulation of dephosphorylation
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of cell cycle
negative regulation of protein modification process
cellular response to DNA damage stimulus
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of cell cycle
regulation of hydrolase activity
intracellular signal transduction
cellular response to stress
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process