TTC1 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: TTC1
Official Name: tetratricopeptide repeat domain 1
Aliases and Previous Symbols: N/A
Entrez ID: 7265
UniProt: Q99614
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-2.26
MS023 7μM R03 exp135	-2.05
AICAR 240μM R05 exp211	-2.03
SB202190 10μM R03 exp148	-1.94
Azithromycin 100μM R08 exp452	-1.86
WYE-354 6μM R02 exp90	-1.79
CFI-400945 25μM R08 exp469	-1.78
TIC10 10μM R08 exp532	-1.72
MK2206 4μM R08 exp504	-1.71

Gene	Correlation
OGFR	0.467
AQR	0.451
TBC1D3H	0.445
PSMA6	0.438
CCNA2	0.438
MED14	0.431
DISP2	0.425
TBC1D3F	0.425
CBWD5	0.423
CDC45	0.42
RRP7A	0.419
ZFAND5	0.415
CHD4	0.415
CBWD3	0.415
C1QTNF9B	0.41
POLR2J3	0.407
AATF	0.405
MYT1L	0.4

Global Fraction of Cell Lines Where Essential: 166/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	4/28
bone	8/26
breast	14/33
central nervous system	5/56
cervix	0/4
colorectal	6/17
esophagus	1/13
fibroblast	0/1
gastric	4/16
kidney	3/21
liver	4/20
lung	26/75
lymphocyte	1/16
ovary	8/26
pancreas	4/24
peripheral nervous system	2/16
plasma cell	1/15
prostate	1/1
skin	8/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 269
Expression level (log2 read counts): 5.01

Expression Distribution

Last modified: 2026/01/07 22:37
by 127.0.0.1