TUBB

Entrez Summary: This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014].
UniProt Summary: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 10μM R04 exp180	-2.75
Parthenolide 2.5μM R05 exp238	-2.66
Torin1 0.08μM R02 exp82	-2.62
MLN-4924 0.2μM R00 exp21	-2.55
TRAIL 5ng/ml R00 exp35	-2.33
TRAIL 50ng/ml R00 exp36	-2.3
Hippuristanol 0.12μM R08 exp488	-2.24
BI-6727 0.0125μM R03 exp97	-2.19
Thimerosal 0.85μM R08 exp529	-2.18
Oligomycin-A 2μM R00 exp25	-2.15
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.1
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.08
CoCl2 18μM R07 exp346	-2.07
Colchicine 0.009μM R05 exp215	-1.99
Vincristine 0.0005μM R04 exp190	-1.96
BI-D1870 2μM R04 exp162	-1.85
BI-2536 0.0042μM R03 exp95	-1.83
Wortmannin 0.5μM R00 exp37	-1.83
Sulforaphane 9μM R08 exp526 no dilution day6	-1.79
Sulforaphane 9μM R08 exp525	-1.78
Bisphenol A 100μM R06 exp269	-1.75
proTAME 5μM R04 exp187	-1.72
Cerivastatin 0.15μM R05 exp226	1.7
Taxol 0.004μM R03 exp103	2.2
Mdivi-1 15μM R05 exp217	3.7

Global Fraction of Cell Lines Where Essential: 690/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	28/28
bone	25/26
breast	32/33
central nervous system	55/56
cervix	4/4
colorectal	13/17
esophagus	12/13
fibroblast	1/1
gastric	14/16
kidney	21/21
liver	17/20
lung	69/75
lymphocyte	16/16
ovary	25/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	26/29
uterus	4/5

Expression Distribution

nuclear envelope lumen
GTPase activating protein binding
MHC class I protein binding
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
leukocyte mediated cytotoxicity
cytoplasmic ribonucleoprotein granule
cell body
cell killing
azurophil granule lumen
ciliary basal body-plasma membrane docking
spindle assembly
structural constituent of cytoskeleton
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
spindle organization
organelle localization by membrane tethering
cytoskeleton-dependent intracellular transport
membrane docking
structural molecule activity
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
regulation of synapse organization
membrane raft
regulation of synapse structure or activity
protein domain specific binding
lymphocyte mediated immunity
protein-containing complex binding
mitotic cell cycle phase transition
cell cycle phase transition
ubiquitin protein ligase binding
microtubule
GTPase activity
cilium assembly
cytoskeleton
cilium organization
GTP binding
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition