UBE4B

Entrez Summary: N/A
UniProt Summary: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-3.55
BML-284 0.09μM R08 exp460	-3.11
GSK461364A 0.005μM R03 exp125	-2.84
Bleomycin 5μM R08 exp459	-2.65
LY2090314 0.003μM R08 exp500 no dilution day6	-2.56
Mdivi-1 15μM R05 exp217	-2.56
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.5
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.24
BI-6727 0.0125μM R03 exp97	-2.23
LY2090314 0.003μM R08 exp499	-2.22
BI-2536 0.0042μM R03 exp95	-2.14
UM131593 0.2μM R03 exp106	-2.05
UMK57 1μM R01 exp59	-2.05
Thapsigargin 0.005μM R07 exp407	-2.04
Epothilone-B 0.0015μM R05 exp231	-2.03
Pyridostatin 4μM R05 exp240	-1.91
Pyronaridine 1μM R06 exp295	-1.85
Vinblastine 0.002μM R01 exp60	-1.85
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.83
UM0125461 0.74μM R02 exp84	-1.82
Tubacin 1.6μM R07 exp416	-1.79
Dexamethasone 0.006μM R07 exp351	-1.71
QNZ 0.01μM R08 exp439	1.73
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.79
Nicotine 3000μM R08 exp510	1.82
Rotenone 0.07μM R08 exp431	1.93
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.94
Bisphenol S 100μM R08 exp458	1.99
Rapamycin 10μM R00 exp30	2.01
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.12
Vemurafenib 6.6μM R08 exp434	2.16
Latrunculin-B 10μM R07 exp374	2.25
B02 10μM R08 exp453	2.26
THZ531 0.11μM R07 exp409	2.32
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.35
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.37
Bortezomib 0.005μM R00 exp6	2.47
Cytochalasin-B 5μM R07 exp349	2.69
THZ531 0.11 to 0.175μM on day4 R07 exp413	3.28
THZ531 0.225μM R08 exp444	4.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

U-box
Ufd2P core

granzyme-mediated apoptotic signaling pathway
ubiquitin-ubiquitin ligase activity
ventricular trabecula myocardium morphogenesis
heart trabecula morphogenesis
trabecula morphogenesis
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue development
protein monoubiquitination
protein autoubiquitination
cardiac muscle tissue morphogenesis
ubiquitin-dependent ERAD pathway
cardiac ventricle morphogenesis
ATPase binding
muscle tissue morphogenesis
muscle organ morphogenesis
ERAD pathway
ubiquitin ligase complex
cardiac chamber morphogenesis
cardiac ventricle development
response to UV
cardiac muscle tissue development
cardiac chamber development
heart morphogenesis
response to endoplasmic reticulum stress
striated muscle tissue development
apoptotic signaling pathway
muscle organ development
muscle tissue development
protein polyubiquitination
response to light stimulus
proteasome-mediated ubiquitin-dependent protein catabolic process
enzyme binding
proteasomal protein catabolic process
response to radiation
muscle structure development
heart development
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
tissue morphogenesis