USP17L17

Entrez Summary: N/A
UniProt Summary: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Alda-1 10μM R06 exp262	-3.03
BI-6727 0.001μM R01 exp42	-2.3
JQ1 0.01μM R03 exp130	-2.17
Wortmannin 0.5μM R00 exp37	-2.17
MLN-4924 0.2μM R00 exp21	-2.15
KU-0063794 3.8μM R02 exp71	-2.07
Cabazitaxel 0.001μM R05 exp223	-2.04
GSK626616 14μM R08 exp485	-1.96
Salubrinal 20μM R07 exp399	-1.78
Rapamycin 2μM R07 exp306	-1.75
Bortezomib 0.05μM R00 exp7	-1.73
GSK-LSD1 10μM R03 exp123	-1.72
SGC0946 7μM R03 exp151	1.7
SGC0649 7μM R03 exp150	1.71
Dimethyloxaloylglycine 11μM R07 exp314	1.75
CB-5083 0.4μM R08 exp468	1.76
IL-3 9ng/ml R08 exp493	1.76
GSK343 3μM R03 exp124	1.81
Ibrutinib 10μM R08 exp442	1.82
Ibrutinib 1μM R07 exp372	1.83
LB-100 4.1μM R02 exp72	1.84
Resminostat 0.5μM R07 exp393	1.86
Diepoxybutane 3μM R07 exp354	1.9
Clomiphene 4.4μM R02 exp68	1.93
Pyrazinamide 100μM R08 exp516	1.93
ABT-702 5μM R07 exp318	1.95
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.29
Beta-Estradiol 0.55μM R07 exp425	2.42
HMS-I2 1μM R06 exp286	2.6
Epigallocatechin gallate 20μM R05 exp230	2.61
Cisplatin 0.35μM R06 exp273	2.74
ZLN024 50μM R08 exp538	2.87
Isoniazid 100μM R08 exp494	3.14

Expression Distribution

cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein deubiquitination
protein modification by small protein removal
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
organic substance catabolic process
cellular catabolic process