VPS35
Gene Information
- Official Symbol: VPS35
- Official Name: VPS35 retromer complex component
- Aliases and Previous Symbols: N/A
- Entrez ID: 55737
- UniProt: Q96QK1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Vps35 |
GO Terms
| positive regulation of locomotion involved in locomotory behavior |
| regulation of terminal button organization |
| positive regulation of dopamine biosynthetic process |
| regulation of dopamine biosynthetic process |
| negative regulation of vacuolar transport |
| negative regulation of late endosome to lysosome transport |
| positive regulation of Wnt protein secretion |
| mitochondrion to lysosome transport |
| mitochondrion-derived vesicle |
| mitochondrion-derived vesicle mediated transport |
| negative regulation of protein catabolic process in the vacuole |
| negative regulation of lysosomal protein catabolic process |
| regulation of Wnt protein secretion |
| regulation of late endosome to lysosome transport |
| retromer, cargo-selective complex |
| tubular endosome |
| regulation of vacuolar transport |
| positive regulation of dopamine receptor signaling pathway |
| regulation of locomotion involved in locomotory behavior |
| positive regulation of dopamine metabolic process |
| positive regulation of catecholamine metabolic process |
| voluntary musculoskeletal movement |
| regulation of lysosomal protein catabolic process |
| positive regulation of cellular amine metabolic process |
| D1 dopamine receptor binding |
| regulation of protein catabolic process in the vacuole |
| mitochondrial fragmentation involved in apoptotic process |
| negative regulation of protein homooligomerization |
| neurotransmitter receptor transport, endosome to plasma membrane |
| neurotransmitter receptor transport, endosome to postsynaptic membrane |
| regulation of dopamine receptor signaling pathway |
| endosome to plasma membrane protein transport |
| positive regulation of cellular response to drug |
| regulation of dendritic spine maintenance |
| protein localization to endosome |
| positive regulation of mitochondrial fission |
| neurotransmitter receptor transport to plasma membrane |
| neurotransmitter receptor transport to postsynaptic membrane |
| negative regulation of protein oligomerization |
| transcytosis |
| establishment of protein localization to postsynaptic membrane |
| regulation of protein homooligomerization |
| retromer complex |
| regulation of catecholamine metabolic process |
| regulation of dopamine metabolic process |
| regulation of mitochondrial fission |
| retrograde transport, endosome to plasma membrane |
| positive regulation of behavior |
| regulation of presynapse assembly |
| regulation of presynapse organization |
| positive regulation of response to drug |
| protein localization to postsynaptic membrane |
| neurotransmitter receptor transport |
| regulation of cellular response to drug |
| receptor localization to synapse |
| regulation of protein oligomerization |
| musculoskeletal movement |
| multicellular organismal movement |
| protein destabilization |
| regulation of postsynaptic membrane neurotransmitter receptor levels |
| establishment of protein localization to plasma membrane |
| lysosome organization |
| lytic vacuole organization |
| apoptotic mitochondrial changes |
| protein localization to synapse |
| regulation of behavior |
| regulation of cellular amine metabolic process |
| negative regulation of cellular protein catabolic process |
| vesicle-mediated transport to the plasma membrane |
| retrograde transport, endosome to Golgi |
| synapse assembly |
| presynapse |
| regulation of postsynapse organization |
| regulation of response to drug |
| regulation of synapse assembly |
| lysosomal transport |
| negative regulation of cellular protein localization |
| positive regulation of mitochondrion organization |
| late endosome |
| vacuole organization |
| vesicle-mediated transport in synapse |
| negative regulation of protein complex assembly |
| negative regulation of protein catabolic process |
| negative regulation of inflammatory response |
| positive regulation of cellular protein catabolic process |
| vacuolar transport |
| positive regulation of canonical Wnt signaling pathway |
| cytosolic transport |
| regulation of macroautophagy |
| positive regulation of Wnt signaling pathway |
| regulation of mitochondrion organization |
| protein localization to plasma membrane |
| negative regulation of neuron death |
| negative regulation of defense response |
| endosome membrane |
| mitochondrial transport |
| positive regulation of protein catabolic process |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| endosomal transport |
| protein localization to cell periphery |
| regulation of cellular protein catabolic process |
| lysosome |
| postsynaptic density |
| negative regulation of cellular catabolic process |
| early endosome |
| protein-containing complex localization |
| establishment of protein localization to membrane |
| synapse organization |
| positive regulation of protein secretion |
| endosome |
| regulation of canonical Wnt signaling pathway |
| regulation of protein stability |
| positive regulation of peptide secretion |
| lysosomal membrane |
| negative regulation of catabolic process |
| regulation of neuron death |
| neuron projection |
| regulation of autophagy |
| regulation of inflammatory response |
| glutamatergic synapse |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| positive regulation of cellular catabolic process |
| negative regulation of response to external stimulus |
| neuronal cell body |
| regulation of protein catabolic process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| positive regulation of catabolic process |
| positive regulation of secretion |
| mitochondrion organization |
| regulation of protein complex assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| protein localization to membrane |
| negative regulation of transport |
| regulation of peptide secretion |
| regulation of cellular protein localization |
| positive regulation of locomotion |
| positive regulation of organelle organization |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| viral process |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cell projection organization |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| symbiotic process |
| regulation of secretion |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| regulation of cellular localization |
| apoptotic process |
| regulation of nervous system development |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| positive regulation of transport |
| regulation of catabolic process |
| negative regulation of cell death |
| intracellular protein transport |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| cell death |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of organelle organization |
| positive regulation of developmental process |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 43/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 4/28 |
| bone | 1/26 |
| breast | 2/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 4/21 |
| liver | 0/20 |
| lung | 4/75 |
| lymphocyte | 0/16 |
| ovary | 2/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 3/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 4/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2543
- Expression level (log2 read counts): 7.39
Expression Distribution
VPS35 Expression in NALM6 Cells: 7.39
