WAPAL

Entrez Summary: N/A
UniProt Summary: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of chromosome condensation
negative regulation of sister chromatid cohesion
regulation of cohesin loading
regulation of protein localization to chromatin
negative regulation of chromatin binding
cohesin complex
regulation of sister chromatid cohesion
regulation of chromatin binding
protein localization to chromatin
synaptonemal complex
negative regulation of sister chromatid segregation
negative regulation of chromosome segregation
negative regulation of DNA replication
positive regulation of fibroblast proliferation
chromosome, centromeric region
protein localization to chromosome
regulation of sister chromatid segregation
regulation of fibroblast proliferation
meiotic chromosome segregation
regulation of chromosome segregation
regulation of DNA replication
chromatin
chromosome
regulation of DNA binding
negative regulation of chromosome organization
meiotic nuclear division
meiotic cell cycle process
negative regulation of binding
nuclear chromosome segregation
meiotic cell cycle
chromosome segregation
nuclear division
organelle fission
negative regulation of cell cycle process
regulation of chromosome organization
negative regulation of organelle organization
regulation of binding
cell division
response to toxic substance
regulation of cellular protein localization