CNOT1
Gene Information
- Official Symbol: CNOT1
- Official Name: CCR4-NOT transcription complex subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 23019
- UniProt: A5YKK6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Not1 |
| DUF3819 |
GO Terms
| CCR4-NOT core complex |
| positive regulation of cytoplasmic mRNA processing body assembly |
| negative regulation of retinoic acid receptor signaling pathway |
| regulation of cytoplasmic mRNA processing body assembly |
| armadillo repeat domain binding |
| positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| retinoic acid receptor binding |
| poly(A)-specific ribonuclease activity |
| negative regulation of intracellular estrogen receptor signaling pathway |
| regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| regulation of retinoic acid receptor signaling pathway |
| CCR4-NOT complex |
| positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| nuclear-transcribed mRNA poly(A) tail shortening |
| regulation of stem cell population maintenance |
| negative regulation of intracellular steroid hormone receptor signaling pathway |
| regulation of intracellular estrogen receptor signaling pathway |
| RNA phosphodiester bond hydrolysis, exonucleolytic |
| estrogen receptor binding |
| gene silencing by miRNA |
| molecular adaptor activity |
| positive regulation of mRNA catabolic process |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| posttranscriptional gene silencing by RNA |
| signal transduction involved in mitotic DNA integrity checkpoint |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| posttranscriptional gene silencing |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| mitotic G1/S transition checkpoint |
| mitotic G1 DNA damage checkpoint |
| G1 DNA damage checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| positive regulation of organelle assembly |
| regulation of intracellular steroid hormone receptor signaling pathway |
| positive regulation of mRNA metabolic process |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| P-body |
| gene silencing by RNA |
| mitotic DNA damage checkpoint |
| negative regulation of G1/S transition of mitotic cell cycle |
| signal transduction in response to DNA damage |
| mitotic DNA integrity checkpoint |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| negative regulation of translation |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| negative regulation of cellular amide metabolic process |
| regulation of G1/S transition of mitotic cell cycle |
| gene silencing |
| mitotic cell cycle checkpoint |
| RNA phosphodiester bond hydrolysis |
| regulation of cell cycle G1/S phase transition |
| cell cycle checkpoint |
| nuclear-transcribed mRNA catabolic process |
| regulation of mRNA catabolic process |
| negative regulation of mitotic cell cycle phase transition |
| mRNA catabolic process |
| regulation of organelle assembly |
| negative regulation of cell cycle phase transition |
| regulation of gene expression, epigenetic |
| protein domain specific binding |
| RNA catabolic process |
| positive regulation of protein complex assembly |
| positive regulation of cell cycle process |
| nucleic acid phosphodiester bond hydrolysis |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| regulation of translation |
| positive regulation of cellular catabolic process |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| regulation of cellular amide metabolic process |
| regulation of mitotic cell cycle phase transition |
| positive regulation of catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| organic cyclic compound catabolic process |
| positive regulation of cellular component biogenesis |
| posttranscriptional regulation of gene expression |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| mRNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| regulation of cellular catabolic process |
| negative regulation of transcription by RNA polymerase II |
| cellular macromolecule catabolic process |
| regulation of cellular component biogenesis |
| regulation of catabolic process |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| negative regulation of protein metabolic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| extracellular space |
| negative regulation of response to stimulus |
| RNA metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CDC73 | 0.516 |
| COPE | 0.476 |
| TCEB3CL2 | 0.47 |
| VASN | 0.462 |
| CDCA3 | 0.455 |
| TBC1D3H | 0.451 |
| MYO1H | 0.45 |
| CHAF1A | 0.446 |
| CKAP5 | 0.445 |
| TCEB3C | 0.441 |
| RPSA | 0.441 |
| PSMB4 | 0.44 |
| SMG7 | 0.439 |
| TCEB3CL | 0.439 |
| C14orf93 | 0.438 |
| TBC1D3F | 0.433 |
| RFFL | 0.431 |
| SMG1 | 0.43 |
| POLD1 | 0.428 |
| ZFAND5 | 0.427 |
| TBC1D3 | 0.424 |
| ZNF830 | 0.423 |
| TBC1D3C | 0.422 |
| SSH2 | 0.421 |
| ZNF106 | 0.421 |
| TBC1D3G | 0.421 |
| NDC1 | 0.411 |
| PAF1 | 0.408 |
| CDK8 | 0.406 |
| CCDC64B | 0.406 |
| ZNF655 | 0.406 |
| PSMA6 | 0.405 |
| BOD1L1 | 0.402 |
| NUP188 | 0.402 |
| DTL | 0.401 |
| SYT9 | 0.4 |
| RBBP5 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 199/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 9/28 |
| blood | 11/28 |
| bone | 5/26 |
| breast | 9/33 |
| central nervous system | 14/56 |
| cervix | 1/4 |
| colorectal | 2/17 |
| esophagus | 4/13 |
| fibroblast | 0/1 |
| gastric | 5/16 |
| kidney | 5/21 |
| liver | 6/20 |
| lung | 20/75 |
| lymphocyte | 8/16 |
| ovary | 5/26 |
| pancreas | 8/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 7/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 9/22 |
| urinary tract | 12/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 387
- Expression level (log2 read counts): 8.83
Expression Distribution
CNOT1 Expression in NALM6 Cells: 8.83
