LCMT1
Gene Information
- Official Symbol: LCMT1
- Official Name: leucine carboxyl methyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51451
- UniProt: Q9UIC8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. {ECO:0000269|PubMed:10600115}.
Pfam Domains GO Terms
Pfam Domains
| LCM |
GO Terms
| protein C-terminal leucine carboxyl O-methyltransferase activity |
| C-terminal protein methylation |
| protein C-terminal carboxyl O-methyltransferase activity |
| S-adenosylmethionine-dependent methyltransferase activity |
| regulation of mitotic spindle checkpoint |
| regulation of spindle checkpoint |
| C-terminal protein amino acid modification |
| regulation of mitotic cell cycle spindle assembly checkpoint |
| regulation of cell cycle checkpoint |
| regulation of mitotic metaphase/anaphase transition |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of mitotic sister chromatid separation |
| regulation of chromosome separation |
| regulation of mitotic sister chromatid segregation |
| regulation of sister chromatid segregation |
| regulation of chromosome segregation |
| regulation of glucose metabolic process |
| G2/M transition of mitotic cell cycle |
| negative regulation of protein complex assembly |
| cell cycle G2/M phase transition |
| protein methylation |
| protein alkylation |
| regulation of cellular carbohydrate metabolic process |
| regulation of mitotic nuclear division |
| regulation of nuclear division |
| regulation of carbohydrate metabolic process |
| macromolecule methylation |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| methylation |
| regulation of chromosome organization |
| post-translational protein modification |
| regulation of mitotic cell cycle phase transition |
| regulation of small molecule metabolic process |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| negative regulation of cellular component organization |
| regulation of cell cycle process |
| regulation of cellular component biogenesis |
| cell cycle process |
| regulation of cell cycle |
| regulation of organelle organization |
| cell cycle |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of cell death |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 41/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 2/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 1/16 |
| ovary | 4/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 7/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2646
- Expression level (log2 read counts): 3.61
Expression Distribution
LCMT1 Expression in NALM6 Cells: 3.61
